Pharmacology - First Aid Flashcards
Calcineurin inhibitors
**Prevent IL2 transcription
Cyclosporine
Tacrolimus
mTOR inhibitor
Sirolimus (Rapamycin)
MABs against IL - 2R
Daclizumab
Basiliximab
Blocks nucleotide synthesis (6-MP precursor)
Azathioprine
6-MP (inhibits PRPP amidotransferase)
Glucocorticoids
Inhibit NF -kappa B
ie decrease cytokine transcription
Class IA
“IA Queen Proclaims Dis pyramid”
Quinidine
Procainamide
Disopyramide
What is the mechanism of Class 1 antiarrhythmics (in general)?
Na+ channel blockers
Slow or block the conduction (esp in depolarized cells) – are state dependent since they selectively depress tissue that is frequently depolarized (tachycardia)
Decrease the slope of phase 0 depol.
What is the mechanism of Class 2 antiarrhythmics (in general)?
Beta blockers.
Metoprolol propanolol esmolol atenolol timolol carvedilol
What is the mechanism of Class 3 antiarrhythmics (in general)?
K+ channel blockers.
Amiodarone
Ibutilide
Dofetilide
Sotalol
What are the Class 1B antiarrhythmics?
Lidocaine
Mexiletine
(Phenytoin)
What are the Class 1C antiarrhythmics?
Flecainide
Propafenone
Which class of anti-arrhythmics prolongs QT?
1A and 3.
What drugs prolong QT?
Antiarrhythmics (Classes IA and III) Antibiotics (macrolides) Antipsychotics (haloperidol) Antidepressants (TCA) Anti-emetics (ondansetron)
How do you treat ß blockers OD?
saline, atropine, glucagon
What is the mechanism of Class 4 antiarrhythmics?
Calcium channel blockers. They decrease the conduction velocity.
Verapamil
Diltiazem
(ie the non-dihydropyridines)
