Neoplasms Flashcards
Aflatoxins
Hepatocellular carcinoma
Alkylating agents
Leukemia/lymphoma
Aromatic amines
Ex. benzidines / 2 - naphthylamine.
Transitional cell carcinoma
Arsenic
Liver: angiosarcoma
Lung: lung cancer
Skin: SqCC
asbestos
bronchogenic carcinoma > mesothelioma
carbon tetrachloride
centrilobular necrosis
fatty change
cigarette smoke
so many carcinomas, except breast!
- pancreatic
- transitional cell
- cervical
- SqCC/ADC of esophagus
- renal cell
- SqCC of larynx
- SqCC of lung
- small cell carcinoma of lung
- pancreatic ADC
Ethanol
SqCC of the esophagus
HCC of liver
ionizing radiation
papillary thyroid carcinoma
nitrosamines (smoked foods)
gastric cancer
radon
lung cancer
2nd leading cause after cigarrette smoke
vinyl chloride
angiosarcoma of the liver
Paraneoplastic syndrome by Hodgkin lymphoma?
Calcitriol (Vit D3) - hypercalcemia
Paraneoplastic syndrome by non-hodgkin lymphoma?
Calcitriol (Vit D3) - hypercalcemia
Paraneoplastic syndrome by Small cell lung carcinoma
ACTH - Cushing syndrome
ADH - SIADH
Ab to presyn. Ca++ channels at NMJ: Lambert-Eaton myasthenic syndrome
Paraneoplastic syndrome by Renal cell carcinoma
ACTH - Cushing syndrome
erythropoietin - polycythemia
PTHrP - hypercalcemia
Paraneoplastic syndrome by intracranial neoplasms
ADH - SIADH
Paraneoplastic syndrome by breast cancer
PTHrP - hypercalcemia
Paraneoplastic syndrome by squamous cell lung carcinoma?
PTHrP - hypercalcemia
Paraneoplastic syndrome by hemangioblastoma
erythropoietin - polycythemia
Paraneoplastic syndrome by HCC
erythropoietin - polycythemia
Paraneoplastic syndrome by leiomyoma
erythropoietin - polycythemia
Paraneoplastic syndrome by pheochromocytoma
erythropoietin - polycythemia
Psammoma bodies
Papillary thyroid carcinoma
Serous cystadenocarcinoma
Meningioma
Malignant mesothelioma
(laminated concentric spherules with dystrophic calcification)
Tumor marker Alkaline phosphatase?
Paget disease of bone
metz to bone or liver
seminoma (placental ALP)
Tumor marker AFP (alpha fetoprotein)
HCC
hepatoblastoma
yolk sac (endodermal sinus)
mixed germ cell tumor
- high levels assoc. with neural tube defects and abdominal wall defects
- low levels assoc. with Down syndrome
Tumor marker ßHCG
Hydratiform moles
choriocarcinomas
testicular cancer
mixed germ cell tumor
*produced by syncytiotrophoblasts of the placenta
Tumor marker CA 15-3/27-29
Breast cancer
Tumor marker CA 19-9
Pancreatic ADC
Tumor marker CA 125
Ovarian cancer
Tumor marker Calcitonin
Medullary thyroid carcinoma
Tumor marker carcinoembryonic antigen (CEA)
Nonspecific! colorectal pancreatic gastric breast medullary thyroid
Tumor marker chromogranin
Neuroendocrine tumor / carcinoid
Tumor marker PSA
Prostate cancer
BPH
prostatitis
