so many carcinomas, except breast! - pancreatic - transitional cell - cervical - SqCC/ADC of esophagus - renal cell - SqCC of larynx - SqCC of lung - small cell carcinoma of lung - pancreatic ADC

Neoplasms Flashcards by U P

Aflatoxins

Hepatocellular carcinoma

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Alkylating agents

Leukemia/lymphoma

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Aromatic amines

Ex. benzidines / 2 - naphthylamine.

Transitional cell carcinoma

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Arsenic

Liver: angiosarcoma
Lung: lung cancer
Skin: SqCC

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asbestos

bronchogenic carcinoma > mesothelioma

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carbon tetrachloride

centrilobular necrosis

fatty change

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cigarette smoke

so many carcinomas, except breast!

pancreatic
transitional cell
cervical
SqCC/ADC of esophagus
renal cell
SqCC of larynx
SqCC of lung
small cell carcinoma of lung
pancreatic ADC

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Ethanol

SqCC of the esophagus

HCC of liver

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ionizing radiation

papillary thyroid carcinoma

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nitrosamines (smoked foods)

gastric cancer

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radon

lung cancer

2nd leading cause after cigarrette smoke

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vinyl chloride

angiosarcoma of the liver

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Paraneoplastic syndrome by Hodgkin lymphoma?

Calcitriol (Vit D3) - hypercalcemia

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Paraneoplastic syndrome by non-hodgkin lymphoma?

Calcitriol (Vit D3) - hypercalcemia

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Paraneoplastic syndrome by Small cell lung carcinoma

ACTH - Cushing syndrome

ADH - SIADH

Ab to presyn. Ca++ channels at NMJ: Lambert-Eaton myasthenic syndrome

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Paraneoplastic syndrome by Renal cell carcinoma

ACTH - Cushing syndrome

erythropoietin - polycythemia

PTHrP - hypercalcemia

Paraneoplastic syndrome by intracranial neoplasms

ADH - SIADH

Paraneoplastic syndrome by breast cancer

PTHrP - hypercalcemia

Paraneoplastic syndrome by squamous cell lung carcinoma?

PTHrP - hypercalcemia

Paraneoplastic syndrome by hemangioblastoma

erythropoietin - polycythemia

Paraneoplastic syndrome by HCC

erythropoietin - polycythemia

Paraneoplastic syndrome by leiomyoma

erythropoietin - polycythemia

Paraneoplastic syndrome by pheochromocytoma

erythropoietin - polycythemia

Psammoma bodies

Papillary thyroid carcinoma
Serous cystadenocarcinoma
Meningioma
Malignant mesothelioma

(laminated concentric spherules with dystrophic calcification)

Tumor marker Alkaline phosphatase?

Paget disease of bone metz to bone or liver seminoma (placental ALP)

Tumor marker AFP (alpha fetoprotein)

HCC hepatoblastoma yolk sac (endodermal sinus) mixed germ cell tumor * high levels assoc. with neural tube defects and abdominal wall defects * low levels assoc. with Down syndrome

Tumor marker ßHCG

Hydratiform moles choriocarcinomas testicular cancer mixed germ cell tumor *produced by syncytiotrophoblasts of the placenta

Tumor marker CA 15-3/27-29

Breast cancer

Tumor marker CA 19-9

Pancreatic ADC

Tumor marker CA 125

Ovarian cancer

Tumor marker Calcitonin

Medullary thyroid carcinoma

Tumor marker carcinoembryonic antigen (CEA)

``` Nonspecific! colorectal pancreatic gastric breast medullary thyroid ```

Tumor marker chromogranin

Neuroendocrine tumor / carcinoid

Tumor marker PSA

Prostate cancer BPH prostatitis