Pharmacology COPY

Question 1

Name a H2 receptor antagonist used to treat peptic ulcer disease

Answer 1

Ranitidine

Question 2

Name a proton pump inhibitor

Answer 2

Omeprazole

Question 3

Which drug may reduce the effects of long-term NSAID treatment?

Answer 3

Misoprostolol (PGE1 analogue)

Question 4

What side effects can a NSAID have on the GI tract?

Answer 4

Gastric bleeding

Mucosal ulceration

Question 5

Why do NSAIDs cause gastric ulceration and bleeding?

Answer 5

Inhibit COX enzyme and thus block PGE formation - PGE reduces gastric acid secretions

Question 6

What are the 3 main aims of drug treatment for peptic ulcers?

Answer 6

Decrease gastric secretions
Increase mucosal resistance
Eradicate H. pylori

Question 7

What do proton pump inhibitors block?

Answer 7

The proton pump on the apical membrane (NOT the ones in tubulovesicles)

Question 8

Name two mucosal strengtheners

Answer 8

Sucralfate

Bismuth chealate

Question 9

Name 2 anti-emetic agents that are antagonists of the 5-HT3 receptor

Answer 9

Ondansetron

Palonosetron

Question 10

Ondansetron (5-HT3 antagonist) is effective in reducing vomiting in chemotherapy patients, but has no effect on motion sickness. True/False?

Answer 10

True

Question 11

Name a muscarinic ACh antagonist that can be used to treat motion sickness

Answer 11

Hyosine

Scopolamine

Question 12

Name a H1 antagonist that can be used to treat motion sickness + nausea/vomiting caused by irritants

Answer 12

Cyclizine

Question 13

Name a dopamine antagonist used for drug-induced and GI disease -induced vomiting

Answer 13

Metoclopramide

Question 14

Name an NK1 antagonist used in conjunction with 5-HT3 antagonist in highly emetogenic chemotherapy

Answer 14

Aprepitant