pharmacology -biologics Flashcards
name 5 biologic TNFa inhibitors
are they monoclonal antibodies
yes, they are monoclonal antibodies:
adalimumab
etanercept
certolizumab
golimumab
inflixumab
name 2 IL6 blockers
are they monoclonal antibodies
yes
tociluzimab
sarilumab
which biologic cannot be given to patients allergic to mice (murine proteins) and why
what is the MOA of this drug?
infliximab
derived from a mouse
a monoclonal antibody TNFa blocker
what is a major issue with monoclonal antibodies
they have serious side effect
when should monoclonal antibodies NOT be administered
if the patient has an active infection or a history of chronic or recurrent infection — infection must be fully terminated
also, pt must be evaluated for risk of TB. if have TB, dont take
pts with multiple sclerosis or epilepsy
specifically for infliximab, in which patients should it not be taken
those allergic to mice/murine proteins – it’s developed from mice
true or false
pts with a history of mild heart failure should not take monoclonal antibodies
true
it will get worse
what is DISLE**
drug induced systemic lupus erythmatosis
GIVEAWAY for side effects of monoclonals
however, lupus is NOT the ONLY autoimmune disease induced by monoclonals
name a serious side effect of monoclonals
these are given by infusion – there can be infusion reactions that can become necrotic
what is abatacept
is it a monoclonal antibody
NOT a monoclonal antibody
costimulatory inhibitor of T cell activation (CD80/86 inhibitor)
binds B7 protein on APCS, preventing release of signal to activate T cells
what is rituximab?
is it a monoclonal
yes, it is a monoclonal
blocks CD20 on B CELLS
causes apoptosis of B cells
name JAK STAT inhibitor**
tofacitinib
(xeljanz,jakvinus)
baricitinib
JAK STAT inhibitors block _____ activity
STAT
is incidence of infections higher when taking monoclonal antibodies or JAK/STAT inhibitors
JAK/STAT – reducing B and T cells
anakinra
IL-1 receptor antagonist
