Pharmacology autonomic nervous system

Question 1

What are the two types drugs that act on muscarinic receptors?

Answer 1

parasympathomimetic(cholinergic)
parasympatholytic (anticolinergic)

Question 2

What does the M2 parasympathetic receptor effect?

Answer 2

heart
PSNS effector cells
cardiac muscles

Question 3

What does the M3 parasympathetic receptor effect?

Answer 3

smooth muscle and exocrine
intestinal smooth muscle and glands

Question 4

What are the two major classes of parasympathomimetic drugs?

Answer 4

cholinergic agonists and
anticholinesterases

Question 5

What is the general function of parasympathomimetic drugs?

Answer 5

stimulate muscle contraction in target organs
Salvation, lacrimation, urination, defecation, digestion (SLUDD)

Question 6

What are the target organs for parasympathomimetic drugs?

Answer 6

paratoid gland, eye, bladder, GI tract

Question 7

What are clinical uses of cholinergic drugs?

Answer 7

-stimulate GI motility and gastric emptying
-stimulate bladder emptying
-constrict the pupil

Question 8

What are the functions of parasympatholytic drugs?

Answer 8

-interrupt parasympathetic nerve impulses in the CNS and ANS
-prevent ach from stimulating collinergic receptors

Question 9

What is the general function of parasympatholytic drugs?

Answer 9

relax muscles in target organs
lack of sweating, blurry vision, urine retention, dry mouth, constipation, tachycardia (ABDUCT)

Question 10

What are the clinical uses of anticholinergic drugs?

Answer 10

-cause bronchodialation, stop diarrhea, stop vomiting, pupil dilation, treat brachycardia

Question 11

What are the two types of drugs that act on adrenergic receptors?

Answer 11

sympathomimetics (adrenergic agonists)
Sympatholytics (antagonists/blockers)

Question 12

What are the three major classes of sympathomimetic drugs?

Answer 12

direct acting, indirect acting, dual acting

Question 13

What is the main location, action, and clinical uses of alpha 1 adrenergic agonist drugs?

Answer 13

location: blood vessels and eye
actions: vasoconstriction and pupil dilation
clinical uses: hypotension, anti arrhythmic, and mydriasis

Question 14

What is the main location, action, and clinical uses of alpha 2 adrenergic agonist drugs?

Answer 14

location: CNS and pancreas
action: decreases sympathetic outflow, decreased NE release, decreased insulin release
clinical uses: sedative, analgesic, muscle relaxation, anxiolysis

Question 15

What is the main location, action, and clinical uses of beta 1 adrenergic agonist drugs?

Answer 15

location: heart and kidney
actions: increased heart rate, increased heart contractility, increased renin release
clinical uses: hypotension, anesthesia, bradychadia

Question 16

What is the main location, action, and clinical uses of beta 2 adrenergic agonist drugs?

Answer 16

location: lungs, uterus, blood vessels
action: broncodialation, uterine relaxation, vasodilation
clinical uses: respiratory disease/asthma and delaying parturition

Question 17

What is the action of alpha 1 antagonists?

Answer 17

treat congestive heart failure/ hypertension and urine retention

Question 18

What is the action of alpha 2 antagonists?

Answer 18

reverse sedation and bradycardic effects of alpha-2 agonsist

Question 19

What is the action of beta 1 antagonists?

Answer 19

treat congestive heart failure/ arrhythmias

Question 20

What is the action of beta 2 antagonists?

Answer 20

no specific uses