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Unit 6 Pharm extras > Pharmacology - Antidotes - Pharmacology - Antidotes (1) > Flashcards

Pharmacology - Antidotes - Pharmacology - Antidotes (1) Flashcards

1
Q

Acetaminophen

A

N-acetylcysteine

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2
Q

Salicylates

A

Alkalnize urine, dialysis

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3
Q

Anticholinesterases, organophosphates

A

Atropine, Pralidoxime

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4
Q

Antimuscarinic (Atropine), anticholinergics

A

Physostigmine (AChE inhibitors)

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5
Q

B-blockers

A

Glucagon

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6
Q

Digitalis

A
  1. Stop digitalis
  2. Normalize K+
  3. Lidocaine
  4. Mg2+
  5. anti-dig Fab fragments
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7
Q

Iron

A

Deferoxamine

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8
Q

Lead

A
  • CaEDTA, Dimercaprol (1st line for adults)
  • Succimer (kids - “sucks” to be a kid with lead poisoning)
  • Penicillamine
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9
Q

Arsenic

A

Dimercaprol, Succimer

Penicillamine

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10
Q

Mercury

A

Dimercaprol, Succimer

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11
Q

Gold

A

Dimercaprol, Succimer

Penicillamine

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12
Q

Copper

A

Penicillamine

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13
Q

Cyanide

A
  1. Nitrite - (oxidizes Hemoglobin to methemoglobin [Fe3+], which has high afinity for CN- but low affinity for O2)
  2. Hydroxocobalamin
  3. Thiosulfate
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14
Q

Methanol, Ethylene glycol

A

Ethanol, dialysis

- Fomepizole

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15
Q

Methemoglobin

A

Methylene blue

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16
Q

Carbon monoxide

A

100% 02, hyperbaric O2

17
Q

Opioids

A

Naloxone/Naltrexone

18
Q

Benzodiazepines

A

Flumazenil

19
Q

TCA’s

A

NaHCO3 (nonspecific) ??

20
Q

Heparin

A

Protamine

21
Q

Warfarin

A

Vit K (hours), Fresh Frozen Plasma (instant)

22
Q

tPA, streptokinase

A

Aminocaproic acid

23
Q

Lead poisoning: LLEEAADD

A
  • Lead Lines on gingivae and long bone epiphyses (on xray)
  • Encephalopathy; Erythrocyte basophilic stippling
  • Abdominal colic; Anemia (sideroblastic)
  • Drops-wrist and foot drop; Dimercaprol as antidote (Succimer for kids)
24
Q

Inducers of CYP450

A 
Quinidine
Barbiturates (phenobarbitol)
Phenytoin
Rifampin
Griseofulvin
Carbemazepine
St. Johns Wort
25
Q

Inhibitors of CYP450

A 
Isoniazid (INH)
Sulfonylureas
Cimetidine
Ketoconazole
Erythromycin
Grapefruit Juice

Unit 6 Pharm extras (4 decks)

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