PHARMACOLOGY

Question 1

what drug class is chlorpromazine?

Answer 1

a phenothiazine based antipsychotic

Question 2

what is chlorpromazine an antagonist for?

Answer 2

dopamine receptors, serotonin 1 and 2 receptors, H1 receptors, alpha 1 and alpha 2 receptors, M1 and M2 receptors

Question 3

what is the mechanisms for chlorpromazine’s antipsychotic actions?

Answer 3

long-term adaptation by the brain to block dopamine receptors

Question 4

what is chlorpromazine used for?

Answer 4

antipsychotic, intractable hiccup, antiemetic

note: no longer used as an antipsychotic

Question 5

what drug class is clozapine?

Answer 5

a psychotropic agent

Question 6

what are the indications for clozapine?

Answer 6

schizophrenia

Question 7

what is clozapine’s mechanism of action?

Answer 7

D2 antagonism to relive positive symptoms and 5HT2A antagonism to alleviate negative symptoms

Question 8

what drug class is haloperidol?

Answer 8

a dopamine receptor antgaonist

Question 9

what is haloperidol used to treat?

Answer 9

schizophrenia

Question 10

what are haloperidol effects?

Answer 10

antipsychotics
sedative
antiemetic

Question 11

what are the possible mechanisms of haloperidol’s action?

Answer 11

1) Depressing the CNS at the subcortical level of the brain, midbrain, and brain stem reticular formation, via inhibition of the ascending reticular activating system of the brain stem (possibly through the caudate nucleus), thereby interrupting the impulse between the diencephalon and the cortex.
2) Antagonizing the actions of glutamic acid within the extrapyramidal system,
3) Inhibiting catecholamine receptors
4) Inhibiting the reuptake of various neurotransmitters in the midbrain
5) Directly affect the chemoreceptor trigger zone (CTZ) through the blocking of dopamine receptors.

Question 12

what drug class is risperidone?

Answer 12

multitarget antipsychotic

Question 13

what is risperidone used to treat?

Answer 13

delusional psychosis, bipolar disorder, psychotic depression

Question 14

what is risperidones mechanism of action?

Answer 14

inhibition of D2 receptors in the limbic system which alleviates symptoms of schizophrenia.
inhibition of 5-HT2 receptors in the mesocortical tract. This causes an excess of dopamine and an increase in dopamine transmission and an elimination of core negative symptoms. Usefully dopamine receptors in the nigrostriatal pathway are not affected and therefore extrapyramidal effects are avoided.
and inhibition of Alpha (1), alpha (2) adrenergic receptors and H1 receptors