Pharmacology

Question 1

Drug monitoring :

1) Statins
2) ACE inhibitors
3) Amiodarone

Answer 1

1) LFT (at baseline, 3 months and 12 months)
2) U&E
3) TFT, LFT (TFT, LFT, U&E, CXR prior to treatment - TFT, LFT every 6 months)

Question 2

Drug monitoring:

1) Lithium
2) Sodium valproate

3) Glitazones

Answer 2

1) Lithium level, U&E, TFT
2) LFT
3) LFT

Question 3

Drug monitoring:

1) Methotrexate
2) Azathioprine

Answer 3

1) U&E, LFT, FBC

2) LFT, FBC

Question 4

P450 Inducers

Answer 4

1) antiepileptics: phenytoin, carbamazepine
2) barbiturates: phenobarbitone
3) rifampicin
4) St John’s Wort
5) chronic alcohol intake
6) griseofulvin
7) smoking (affects CYP1A2, reason why smokers require more aminophylline)

Question 5

P450 Inhibitors

Answer 5

1) antibiotics: ciprofloxacin, erythromycin
isoniazid
2) cimetidine,omeprazole
3) amiodarone
4) allopurinol
5) imidazoles: ketoconazole, fluconazole
6) SSRIs: fluoxetine, sertraline
7) ritonavir
8) sodium valproate
9 ) acute alcohol intake
10) quinupristin

Question 6

Inducers make drug less effective

Answer 6

True