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Boards studying > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What is leuprolide?

A

A gnRH analog

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2
Q

What does Leuprolide do to LH/FSH when pulastile? Continuous?

A

Agonist when pulsatile

Antagonist when continuous

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3
Q

What is leuprolide used for clinically (pulsatile)?

A

Infertility

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4
Q

What is leuprolide used for clinically (continuous)? (3)

A

Prostate cancer

Uterine fibroids

Precocious puberty

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5
Q

What does testosterone do to lipoproteins?

A

Increases LDL, decreases HDL

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6
Q

What is finasteride?

A

A 5 alpha reductase inhibitor

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7
Q

What is finastride used to treat (2)?

A

BPH

Male pattern baldness

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8
Q

What is flutamide?

A

A competitive inhibitor of the testosterone receptor

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9
Q

What is flutamide used to treat?

A

Prostate carcinoma

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10
Q

What does ketoconazole do?

A

Inhibits steroid synthesis

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11
Q

What does spironolactone do steroid wise?

A

Inhibits steroid binding

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12
Q

What are ketoconazole and spironolactone used to treat?

A

PCOS

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13
Q

What are the side effects of ketoconazole and spironolactone? (2)

A

Gynecomastia

Amenorrhea

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14
Q

What do estrogens (ethinyl estradiol, DES, mestranol) increase the risk of?

A

Endometrial cancer

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15
Q

What does DES increase the risk of to females exposed in utero?

A

Clear cell adenocarcinoma of the vagina

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16
Q

What class of drugs do comiphene, tamoxifen and raloxifene belong to?

A

Selective estrogen receptor modulators

17
Q

What does Clomiphene do? (2)

A

Partial agonist at estrogen receptors in the hypothalamus

Results in increased release of LH and FSH from the pituitary

18
Q

What is clomiphene used to treat? (2)

A

Infertility and PCOS

19
Q

What does tamoxifen do?

A

ER antagonist on breast tissue

20
Q

What is tamoxifen used to treat?

A

ER positive breast cancer

21
Q

What does raloxifene do?

A

Agonist for ER on bone

Reduces bone resorption

22
Q

What is raloxifene used to treat?

A

Osteoporosis

23
Q

What are anastrozole/exemestane?

What are they used for?

A

Aromatase inhibitors

Post-menopausal women with breast cancer

24
Q

What do progestins do?

A

Bind progestin receptors-reduce growth and increase vascularization of the endometrium

25
Q

What is progestin used for? (3)

A

OCT

Treatment of endometrial cancer

Abnormal uterine bleeding

26
Q

What is Mifepristone (RU 486)?

A

Competitive inhibitor of the progesterone receptor

27
Q

What is mifepristone (RU 486) used for?

What is it administerd with? What class of drugs is this

A

Termination of pregnancy

Misoprostol (PGE1)

28
Q

What is terbutaline?

What is it used for?

A

B2 agonist that relaxes the uterus

Used to reduce premature uterine contractions

29
Q

What is Tamulosin?

A

Alpha 1 antagonist, inhibits SMC contraction in the prostate

30
Q

What is tamulosin used to treat?

A

BPH

31
Q

What is the risk for patients taking nitrates and viagra?

A

Life threatening hypotension

32
Q

What is danazol?

A

A synthetic androgen that acts as a partial agonist at androgen receptors

33
Q

What is danazol used to treat?

A

Endometriosis (endometrial cells proliferate outside of the uterus-usually in abdomen)

Hereditary angioedema

34
Q

What is daclizumab?

A

Antibody against IL-2 receptor on activted T cells

35
Q

What is daclizumab used for?

A

Prevent rejection in renal allograft recipients

36
Q

What are the short acting Benzo’s?
Do they increase the risk of fall?
What is their side effect

A

Alprazolam
Trizolam
Oxazepam

Low fall risk
High risk of withdrawl

37
Q

What are the medium acting benzos?

A

Estazolam
Lorazepam
Temazepam

38
Q

What are the long acting benzos?

What is their major side effect?

A

Chlordiazepoxide
Clorazepate
Diazepam
Flurazepam

Increase fall risk

Boards studying (5 decks)

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