Pharmacology Flashcards
What is Naproxen?
Longer lasting alternative to Ibuprofen for pain with inflam component
What is Triamcinolone?
Powerful steroid anti-inflam given as epidural injection (not analgesic)
What is oxycodone?
Strong opioid analgesic
What is the MOA of Naproxen?
- NSAID - inhibits PGHS
- PGE2 normally sensitises noiciception + potentiated local inflam
What is the MOA of Triamcinolone?
- Glucocorticoid steroid analogue anti-inflam with potent systemic effects
- Steroid-receptor complexes = transcriptional regulators = up reg anti-inflam mediators = down reg pro-inflam mediators
What is the MOA of Oxycodone?
- Mu-opioid receptor agonist acting in CNS
- Opioid receptor activation = K+ efflux and Ca2+ channel closing in neurones suppressing release of pain NT’s
BUT
facilitates nociceptive pathway activation in PAG region
What are the ADR’s of Naproxen?
Predisposes to GI ulcers/bleeding
Renal impairment
What are the CI’s pf Naproxen?
Already on NSAIDs
Renally impaired
Gastric ulcer
What are the ADR’s of Triamcinolone?
Cushings syndrome
Weight gain
Hyperglycaemia
Immune suppression
What are the CI’s of Triamcinolone?
Cushings
Diabetic
GI ulcer with no PPI cover
Already immunosuppressed
What are the ADR’s of Oxycodone?
Constipation
Nausea
Resp depression
Dependence
What are the ADR’s of Oxycodone?
Resp depression
Raised ICP/head injury
Already taking opioid
