Pharmacology Flashcards
What is hydrocortisone used for?
Addison’s
What is levothyroxine used for?
Hypothyroidism
What is carbimazole used for?
Hyperthyroidism in Grave’s disease
What is the MOA of insulin?
Activates insulin receptor > phosphorylation of insulin elements > upregulates glucose traffic into cells via GLUT activity + increased glycogen synthesis
What is the MOA of hydrocortisone?
- Exogenous form of cortisol
- Forms active complex with nuclear glucocorticoid receptors
- Upregulate gluconeogenesis + suppresses inflam immune response
What is the MOA of levothyroxine?
- Synthetic thyroxine T4 = converted to T3
- Both can bind to nuclear thyronine receptors
= metabolic effects through transcriptional regulation of metabolism associates genes
What is the MOA of carbimazole?
- Pro-drug converted to methimazole which inhibits thyroid peroxidase
- Blocks iodination of thyroglobulin needed for T3 + T4
What are the ADR’s of insulin?
Overdose hypoglycaemia
Coma
Death
What are the CI’s of insulin?
B blockers (enhances/masks hypoglycaemia)
What are the ADR’s of hydrocortisone?
Weight gain
Fluid retention
Hyperglycaema
Cushings syndrome
What are the CI’s of hydrocortisone?
Immune suppressed
Active fungal infection
Diabetic
What are the ADR’s of levothyroxine?
Tremor Cardiac arhythmias Excitability Diarrhoea Hot flushes
What are the CI’s of levothyroxine?
Ischaemic cardiac disease
Thyrotoxicosis or Grave’s disease
What are the ADR’s of carbimazole?
Joint pain Fever Headache Rash Taste-disturbances
What are the CI’s of carbimazole?
Patient warfarinised
