Pharmacology

Question 1

1 allergic reaction

Answer 1

NMBDs

Question 2

Myasthenia

Answer 2

Resistance to SUX

More sensitive to ND-NMBDs

Question 3

LEMS

Answer 3

MORE sensitive to BOTH

Question 4

Side effects of Terbutaline

Answer 4

hypoK, hypotension, MI, pulmonary edema

hypERglycemia

Question 5

Drugs that DO NOT cross the placenta

Answer 5

tHINGS:
heparin
insulin
ND-NMBDs
Glyco
SUX

Question 6

Level of Mag with loss of DTRs

Answer 6

10-12

Goal = 4-8
Res paralysis = 15
Cardiac arrest = 25
Tx = Ca

NMDA & L-type Ca channels

Question 7

Mechanism of Milrinone

Answer 7

Dec hydrolysis of cAMP –> inc ionotropy

Pulmonary vasodilator

Question 8

Inhibitors of CYP1A2

Answer 8

Fluoroquinolones
Fluvoxamine
Verapamil

Avoid using Tizanidine with these

Question 9

Drugs with inc [plasma] in ESLD

Answer 9

Thiopental
Benzos
Alfentanil

Question 10

Sodium nitroprusside

Answer 10

Cyanide toxicity - >1mg/kg in 2 hours
Signs - inc MvO2, acidosis

Thiocyanate toxicity - long term SNP or renal failure
Signs - N/V, seizure, spasms

Inc cGMP
May induce coronary steal/reduce CPP

Question 11

Phenytoin MOA

Answer 11

Blocks Na channels - shortens ventricular depolarization

Gingival hyperplasia
Initially enhances ND-NMBD then resistance with chronic use

Question 12

Antibiotic that cover both MRSA and gram-negative

Answer 12

Tigecycline

Question 13

Drugs dosed on total body weight

Answer 13

Sux - dec plasma colinesterase

Question 14

Drugs dosed on lean body weight

Answer 14

opioids

induction meds

Question 15

Drugs dosed on ideal body weight

Answer 15

ND-NMBDs

Question 16

Allergy to amioamides cause

Answer 16

Methylparaben

With epi = metabisulfite

Question 17

Pain drugs that lower seizure threshold

Answer 17

Tramadol
TCAs (amytriptyline)

Question 18

NMBD with highly active metabolite

Answer 18

Vecuronium - 3-desacetyl

Question 19

Dose of ropivicaine for caudal to cover low thoracic dermatomes (inguinal hernia)

Answer 19

1ml/kg

Question 20

Sarin gas attack

Answer 20

Sx - salivation, lacrimation, urination, diaphoresis, vomiting, bronchospasm, blurred vision (excess Ach from ACH-esterase inhibitor)

Tx = atropine + pralidoxime

Question 21

Mechanism of Amicar and TXA

Answer 21

competitive inhibition of plasmin

Question 22

Mechanism of sulfur mustard agent

Answer 22

blistering vesicant - attacks DNA, RNA and cell membranes

Question 23

Fenoldopam mech

Answer 23

D1 agonist

Question 24

Mechanism of plavix and ticlopidine

Answer 24

ADP receptor inhibition

Question 25

Mechanism of abciximab, tirofiban

Answer 25

GP IIb/IIIa inhibition

Question 26

NMBD dosing after burns

Answer 26

Increase

Question 27

Maximum tumescent lidocaine

Answer 27

55mg/kg

Question 28

Mech of Mag interaction w/ NMBDs

Answer 28

Competes with Ca

Inc sensitivity to both NMBDs

Question 29

Amount of epi in 1:200,000

Answer 29

5mcg/ml

Question 30

Med interactions with fluoxetine

Answer 30

Inc [plasma] of TCAs, BBs, antiarrythmics

Question 31

Drug approved for HIT

Answer 31

Argatroban

Question 32

Drugs removed/metabolized by the lungs

Answer 32

Local
Opioids
Propofol, ketamine
NE, dopamine

NOT metabolized = NMBDs, Epi

Question 33

Effect of SNP A118G response to morphine

Answer 33

Inc requirement

Question 34

Herbal medicine that decreases therapeutic level of warfarin

Answer 34

St Johns Wort

Question 35

Electrolyte changes with acetazolamide

Answer 35

hyperchloremic metabolic acidosis
Dec Na
Dec Bicarb