Pharmacology Flashcards

1
Q

Are medication errors common or rare

A

Common

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2
Q

Are medication errors usually preventable

A

Yes

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3
Q

Which patients are most at risk for errors

A

Those undergoing cardiothoracic surgery, vascular surgery, or neurosurgery

Those with complex conditions

Those in the emergency room

Those looked after by inexperienced doctors

Older patients

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4
Q

Examples of cognitive errors

A

Incorrect Dx

Choosing the wrong medication

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5
Q

Factors that could increase the rate of medication errors

A

More rapid throughput of patients
New drug developments, extending medicines into new areas
Increasing complexity of medical care
Increased specialisation
Increased use of medicines generally
Sicker and older patients, more vulnerable to adverse effects

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6
Q

People related causes of medication errors

A
Fatigue 
Hunger
Concentration 
Distraction 
Lack of training 
Lack of access to information 
Other factors
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7
Q

Common prescribing errors

A
Wrong drug (e.g. drugs that sound alike)
Wrong dose 
Inappropriate Units
Poor/illegible prescriptions
Failure to take account of drug interactions
Omission
Wrong route/multiple routes (IV/SC?PO)
Calculation errors (important in Paediatrics)
Poor cross referencing
Infusions with not enough details of diluent, rate etc. Poor cross-referencing between charts
Once weekly drugs
Multiple dose changes
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8
Q

What should you always check with a patient when prescribing

A
Age
Weight 
Renal and hepatic function 
Concurrent disease
Lab results 
Concurrent medicaitons
Allergies 
Medical/surgical and FH 
Pregnancy
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9
Q

Is it okay to use abbreviations?

A

Don’t use abbreviations!!

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10
Q

Things to avoid when writing a prescription

A

DO NOT use abbreviations
Avoid decimal points if possible
Never leave a decimal point naked
Never use a terminal zero (e.g 1g not 1.0g)
Leave a space between drug name and dose
Don’t use trade names unless you have to

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11
Q

5Rs of medication error prevention

A
Right patient 
Right Drug 
Right dose 
Right route 
Right time
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12
Q

Which formularies can you refer to

A
National Formularies (e.g BNF)
Grampian joint formulary 
WHO
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13
Q

Which organisation is responsible for licensing medications

A

MHRA

Medicines and Healthcare products Regulatory Agency

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14
Q

Role of MHRA

A

Ensures that human medicines meet acceptable standards on safety, quality and efficacy.

Ensures that the sometimes difficult balance between safety and effectiveness is achieved.

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15
Q

Role of Scottish Medicines Consortium

A

Provide advice to NHS Scotland regarding all new licenced medicines, new formulations of existing medicines and new indications for established products.

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16
Q

Before a medicine can be routinely prescribed in Scotland who has to accept it

A

SMC

Scottish Medicine Consortium

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17
Q

GMC guidance for unlicensed medication prescribing

A

“You should usually prescribe licensed medicines in accordance with the terms of their licence. However, you may prescribe unlicensed medicines where, on the basis of an assessment of the individual patient, you conclude, for medical reasons, that it is necessary to do so to meet the specific needs of the patient.”

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18
Q

What does the GMC expect when prescribing unlicensed medication

A

You to:
Carefully consider the Rx you prescribe
Be able to justify your decision

19
Q

3 classes of medications according to Human Medicines Regulation 2012

A

Prescription only medication (POM)
Pharmacist (P) medicines
General sales list medicines (GSL)

20
Q

What class of medication does new medicines have to be in the first instance

A

Prescription only

21
Q

What are general sales list and pharmacy medicines collectively known as

A

Over the counter

22
Q

Where can general sales list drugs be sold

A

Registered pharmacies

Also in other retail outlets

23
Q

Example of general sales list medication

A

Paracetamol

24
Q

Where can Pharmacy (P) medicine be sold

A

Sold from a registered pharmacy premises by a pharmacist or a person acting under the supervision of a pharmacist.

25
Q

What does the pharmacist involved in the sale of P medicines need to check for

A

CI or problems before the sale

26
Q

Where can Prescription only medicines be given

A

Written by an appropriate practitioner before it can be sold or supplied.

27
Q

POM appropriate practitioners

A
doctor
dentist
supplementary prescriber
nurse independent prescriber
pharmacist independent prescriber
28
Q

Requirements of a general prescription in primary care

A

Name and address of patient;

Age of patient if under 12 years old;

Details of drug name, formulation, dose, frequency and quantity to be dispensed;

Signed in indelible ink by appropriate practitioner;

Date on which is signed;

Type of prescriber and address

29
Q

Controlled drugs prescription requirements

A

Schedules 2, 3, and 4 limited to supply of up to 30 days’ treatment.

Specify formulation and strength.

Specify dose

Total amount in words and figures

30
Q

What is the BNF

A

It details all medicines that are generally prescribed in the UK,

31
Q

What does the BNF detail information about

A
Indications
Dosages
CI 
Cautions 
SE 
Medicinal products
32
Q

Where can the BNF be accessed

A

Book
Online
App

33
Q

What are the 2 types of BNF

A

General

Children only

34
Q

Which evidence based national guidelines are sued

A

SIGN

NICE

35
Q

Which should liquids be prescribed

A

Milligrams of the active ingredient

Not mL as many formations may exist

36
Q

Roles of Medicines and Healthcare Products Regulatory Agency (MHRA)

A

Post-marketing surveillance – ADRs and incidents

Assessment & Authorisation of medicinal products for sale in UK

Devices

Quality control

Internet sales & counterfeiting

Clinical Trials regulation

Statutory controls

Promotion of safe use

Manage British Pharmacopoeia & Clinical Practice Research Database

37
Q

Role of Yellow Card Scheme Scotland

A

For reporting adverse drug reactions to medicines

38
Q

Principle remit of Scottish Medicines Consortium (SMC)

A

to make decisions on the cost effectiveness of
new/existing pharmaceutical products in respect of their use in
NHS Scotland

39
Q

3 outcomes for a drug after assessment by SMC

A

Approved for use
Approved for restricted use
Not recommended

40
Q

Why might a drug not be recommended by SMC

A

Clinical effectiveness not convincing
Cost-effectiveness not demonstrated
No submission by manufacturer

41
Q

Remit of Patient Access Schemes Assessment Group (PASAG)

A

Remit is to Advise on acceptability of Patient Access Schemes within NHS Scotland.

42
Q

Reasons for new Formulary additions

A

Unequivocal evidence of efficacy:

available for general use

available for restricted use/specialist supervision

eestricted funding approved by NHS Grampian to support protocol under strict use

approved by SMC cost effective alternatives available not recommended for use in Grampian

43
Q

Reasons for Formularly Disinvestment

A

Recommend removal from Grampian Joint Formulary

evidence for superior efficacy/safety/kinetics now available for alternative product

evidence from major outcome studies now favour an alternative product

evidence of superior cost/benefit now available for an alternative product

evidence that this product is of limited clinical effectiveness