Pharmacology Flashcards

1
Q

Are medication errors common or rare

A

Common

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2
Q

Are medication errors usually preventable

A

Yes

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3
Q

Which patients are most at risk for errors

A

Those undergoing cardiothoracic surgery, vascular surgery, or neurosurgery

Those with complex conditions

Those in the emergency room

Those looked after by inexperienced doctors

Older patients

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4
Q

Examples of cognitive errors

A

Incorrect Dx

Choosing the wrong medication

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5
Q

Factors that could increase the rate of medication errors

A

More rapid throughput of patients
New drug developments, extending medicines into new areas
Increasing complexity of medical care
Increased specialisation
Increased use of medicines generally
Sicker and older patients, more vulnerable to adverse effects

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6
Q

People related causes of medication errors

A
Fatigue 
Hunger
Concentration 
Distraction 
Lack of training 
Lack of access to information 
Other factors
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7
Q

Common prescribing errors

A
Wrong drug (e.g. drugs that sound alike)
Wrong dose 
Inappropriate Units
Poor/illegible prescriptions
Failure to take account of drug interactions
Omission
Wrong route/multiple routes (IV/SC?PO)
Calculation errors (important in Paediatrics)
Poor cross referencing
Infusions with not enough details of diluent, rate etc. Poor cross-referencing between charts
Once weekly drugs
Multiple dose changes
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8
Q

What should you always check with a patient when prescribing

A
Age
Weight 
Renal and hepatic function 
Concurrent disease
Lab results 
Concurrent medicaitons
Allergies 
Medical/surgical and FH 
Pregnancy
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9
Q

Is it okay to use abbreviations?

A

Don’t use abbreviations!!

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10
Q

Things to avoid when writing a prescription

A

DO NOT use abbreviations
Avoid decimal points if possible
Never leave a decimal point naked
Never use a terminal zero (e.g 1g not 1.0g)
Leave a space between drug name and dose
Don’t use trade names unless you have to

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11
Q

5Rs of medication error prevention

A
Right patient 
Right Drug 
Right dose 
Right route 
Right time
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12
Q

Which formularies can you refer to

A
National Formularies (e.g BNF)
Grampian joint formulary 
WHO
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13
Q

Which organisation is responsible for licensing medications

A

MHRA

Medicines and Healthcare products Regulatory Agency

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14
Q

Role of MHRA

A

Ensures that human medicines meet acceptable standards on safety, quality and efficacy.

Ensures that the sometimes difficult balance between safety and effectiveness is achieved.

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15
Q

Role of Scottish Medicines Consortium

A

Provide advice to NHS Scotland regarding all new licenced medicines, new formulations of existing medicines and new indications for established products.

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16
Q

Before a medicine can be routinely prescribed in Scotland who has to accept it

A

SMC

Scottish Medicine Consortium

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17
Q

GMC guidance for unlicensed medication prescribing

A

“You should usually prescribe licensed medicines in accordance with the terms of their licence. However, you may prescribe unlicensed medicines where, on the basis of an assessment of the individual patient, you conclude, for medical reasons, that it is necessary to do so to meet the specific needs of the patient.”

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18
Q

What does the GMC expect when prescribing unlicensed medication

A

You to:
Carefully consider the Rx you prescribe
Be able to justify your decision

19
Q

3 classes of medications according to Human Medicines Regulation 2012

A

Prescription only medication (POM)
Pharmacist (P) medicines
General sales list medicines (GSL)

20
Q

What class of medication does new medicines have to be in the first instance

A

Prescription only

21
Q

What are general sales list and pharmacy medicines collectively known as

A

Over the counter

22
Q

Where can general sales list drugs be sold

A

Registered pharmacies

Also in other retail outlets

23
Q

Example of general sales list medication

A

Paracetamol

24
Q

Where can Pharmacy (P) medicine be sold

A

Sold from a registered pharmacy premises by a pharmacist or a person acting under the supervision of a pharmacist.

25
What does the pharmacist involved in the sale of P medicines need to check for
CI or problems before the sale
26
Where can Prescription only medicines be given
Written by an appropriate practitioner before it can be sold or supplied.
27
POM appropriate practitioners
``` doctor dentist supplementary prescriber nurse independent prescriber pharmacist independent prescriber ```
28
Requirements of a general prescription in primary care
Name and address of patient; Age of patient if under 12 years old; Details of drug name, formulation, dose, frequency and quantity to be dispensed; Signed in indelible ink by appropriate practitioner; Date on which is signed; Type of prescriber and address
29
Controlled drugs prescription requirements
Schedules 2, 3, and 4 limited to supply of up to 30 days' treatment. Specify formulation and strength. Specify dose Total amount in words and figures
30
What is the BNF
It details all medicines that are generally prescribed in the UK,
31
What does the BNF detail information about
``` Indications Dosages CI Cautions SE Medicinal products ```
32
Where can the BNF be accessed
Book Online App
33
What are the 2 types of BNF
General | Children only
34
Which evidence based national guidelines are sued
SIGN | NICE
35
Which should liquids be prescribed
Milligrams of the active ingredient Not mL as many formations may exist
36
Roles of Medicines and Healthcare Products Regulatory Agency (MHRA)
Post-marketing surveillance – ADRs and incidents Assessment & Authorisation of medicinal products for sale in UK Devices Quality control Internet sales & counterfeiting Clinical Trials regulation Statutory controls Promotion of safe use Manage British Pharmacopoeia & Clinical Practice Research Database
37
Role of Yellow Card Scheme Scotland
For reporting adverse drug reactions to medicines
38
Principle remit of Scottish Medicines Consortium (SMC)
to make decisions on the cost effectiveness of new/existing pharmaceutical products in respect of their use in NHS Scotland
39
3 outcomes for a drug after assessment by SMC
Approved for use Approved for restricted use Not recommended
40
Why might a drug not be recommended by SMC
Clinical effectiveness not convincing Cost-effectiveness not demonstrated No submission by manufacturer
41
Remit of Patient Access Schemes Assessment Group (PASAG)
Remit is to Advise on acceptability of Patient Access Schemes within NHS Scotland.
42
Reasons for new Formulary additions
Unequivocal evidence of efficacy: available for general use available for restricted use/specialist supervision eestricted funding approved by NHS Grampian to support protocol under strict use approved by SMC cost effective alternatives available not recommended for use in Grampian
43
Reasons for Formularly Disinvestment
Recommend removal from Grampian Joint Formulary evidence for superior efficacy/safety/kinetics now available for alternative product evidence from major outcome studies now favour an alternative product evidence of superior cost/benefit now available for an alternative product evidence that this product is of limited clinical effectiveness