Pharmacology Flashcards
DOC in organ or tissue transplant
Cyclosporine
Molecular target of sirolimus
mTOR
Monoclonal antibodies used to block IL-2 receptors (CD25) in kidney transplants
- Daclizumab
* Basiliximab
Monoclonal antibody that binds to T3 (CD3) on thymocytes
Muromonab
Glycoprotein 2b/3a inhibitors
- Abciximab
- Eptifibatide
- Tirofiban
Drugs that prevent IL-2 transcription
- Cyclosporine
* Tacrolimus
Drug that prevents response to IL-2
Sirolimus
Drug that is associated with invasive CMV infection
Mycophenolate mofetil
Antibody against complement C5 protein used in paroxysmal nocturnal hemoglobinuria
Eculizumab
Antibody against alpha 4 integrin used in multiple sclerosis
Natalizumab
DOC for lead poisoning in kids and adults
- Adults: dimercaprol and EDTA
* Kids: succimer
Mechanism of action of ruxolitinib
JAK1/2 inhibitor
Only oral direct thrombin inhibitor
Dabigatran
Drug used for reversal of dabigatran
Idarucizumab
Thrombolytic that is clot-specific
Alteplase
ADP receptor inhibitor that is reversible
Ticagrelor
EGFR tyrosine kinase inhibitor
Erlotinib
DOC for hairy cell leukemia
Cladribine
Calcineurin inhibitors
- Cyclosporine
* Tacrolimus
Clinical use of muromonab
Used to treat acute rejection
Difference between 6-mercaptopurine and 6-thioguanine
6-thioguanine can be used in patients taking allopurinol
Mechanism of action of cytarabine
Direct inhibition of DNA synthase, pyrimidine antimetabolite
DOC in patients with heparin-induced thrombocytopenia
Bivalirudin
Psoriaris can be exacerbated by intake of which antimicrobial
Chloroquine
