Pharmacology

Question 1

Barbiturates MOA

Answer 1

Causes a decreased rate of dissociation of the inhibitory NT, GABA

Question 2

Thiopental/Methohexital

Answer 2

Ultra-short acting
Decreases CSF pressure and IOP
C/I porphyria
Methohexital more potent 3:1, more SE (involuntary movements, hiccups, resp irregularities)

Question 3

Pentobarbital

Answer 3

Use: Reduce ICP, RSE

C/I allergy, emesis, DI, prolonged recovery, cardiac dysfxn

Question 4

Benzodiazepines

Answer 4

Enhance affinity of inhibitory NT GABA for their receptors

Question 5

Diazepam

Answer 5

Less cardiac depression than barbiturates

Question 6

Midazolam

Answer 6

Short acting

2-3x more potent than diazepam