Pharmacology Flashcards
Which of the following statements is tre regarding drug metabolism *
A.Phase 1 reactions convert the parent drug to a more polar or more reactive product
B.Phase 2 reactions involve conjugation of subgroups
C.Drugs may undergo phase II metabolism before or after phase II
D.Hydrolysis is an example of a phase I reaction
E.All of the above
e
Cytochrome P450 inhibitor, EXCEPT
A.Cimetedine B.Ketoconazole C.Ritonavir D.Azithromycin E.None of the above
c
Partially activates nicotinic receptors, may be used to treat nicotine addiction *
A.Bethanecol B.Varenicline C.PIlocarpine D.Carbachol E. Edrophonium
a
Which of the following is a cholinergic antagonist used to treat Parkinson’s disease
A.Galantamine B.Rivastigmine C.Benztropine D.Tacrine E.Donepezil
c
Activates both β1 and β2 receptors
A.Isoproterenol B.Dobutamine C.Albuterol D.Propanolol E.Metropolol
d
Which of the following treatments of glaucoma, act by increasing outflow through the Canal of Schlemm
A.Pilocarpine B.Timolol C.Mannitol D.Epinephrine E.Latanoprost
a
Which of the following anti-hypertensives should be avoided during pregnancy?
A.Methyldopa B.Hydralazine C.Nifedepine D.Enalapril E.Labetalol
d
The following are known to cause gingival hyperplasia, EXCEPT
A.Nifedepine B.Verapamil C.Diltiazem D.Cyclosporine E.Phenytoin
c
In the treatment of angina pectoris, the combined use of a Nitrate and a β-Blocker or a Calcium channel blocker has no effect on which of the following factors? *
A.Heart rate B.Arterial pressure C.End-diastolic pressure D.Ejection time E.Net myocardial O2 requirement
d
Which of the following antiarrythmic drugs prolongsthe AP duraton
A.Disopyramide B.Lidocaine C.Tocainide D.Flecainide E.Phenytoin
b
Which of the following when given with statins increases the risk of myopathy and rhabdomyolysis?
A.Ezetimibe B.Gemfibrozil C.Niacin D.Cholestyramine E.Sitosterol
d
A newborn presents with cyanosis and shortness of breath, history also reveals that the mother is a known diabetic. Chest x-ray was done showing a cardio-mediastinal silhouette appearing as an “egg on a string”. Which of the following drugs is beneficial to the patient’s condition?
A.Indomethacin B.Ibuprofen C.Alprostadil D.Both A and B E.All of the above
a
The following statements are true, EXCEPT
A.Salmeterol increases asthma mortality when used alone
B.Ipatropium is more effective and less toxic than beta-agonists in patienst with COPD
C.Monteleukast has no bronchodilator action
D.Beta agonists are given as antidote for Theophylline overdose
E.Theophylline has a narrow therapeutic window
a
ntiplatelet drug that act by inhibiting phosphodiesterase III and increases cAMP in platelets and blood vessels
A.Abciximab B.Clopidogrel C.Aspirin D.Ticlopidine E.Cilostazol
c
Antiseizure drug used for Absence seizures, acts by decreasing Ca2+ currents (T-type) in the thalamus
A.Lamotrigine B.Valproic acid C.Topiramate D.Levetiracetam E.Ethosuximide
b
