Pharmacology Flashcards
Regarding cyclophosamide
What type of drug is it
When is it’s main side effect
Alkylating chemotherapy agent
Haemorrhagic cystitis
Paclitaxel
What are the side effects
Alopecia
Neutropenia
Arrhythmia
Sensory peripheral neuropathy
Vincristine
What are the side effects
When is it used
Where is it metabolised
Neurotoxicity
Myelosupression
Gestational trophoblastic disease
Liver
Cisplatin
How is it excreted
Side effects
By the kidney
Nephrotoxic
Hearing loss and tinnitus
Mainly replaced by carboplantin - less toxic platinum agent for ovarian Ca
What is the first line treatment for complicated malaria
IV artusenate
What is first line for uncomplicated malaria
Quinine and clindamycin
Uncomplicated = parasites <2%
What is first line for uncomplicated malaria with P.ovale or P.malariae
Chloroquine
Give advice
Vomiting after oral medication for uncomplicated malaria
Repeat oral quinine and clindamycin with antiemetic
If still vomiting - IV therapy
IV quinine + IV clindamycin + 5% dextrose
Which antidepressants have the lowest levels in breast milk
Imipramine, nortryptiline, sertraline
Which SSRI is associated with heart defects in the first trimester
Paroxetine
Associated right ventricular outflow tract obstruction
Also anencephaly, craniosynostosis and onphalocele
Overall which SSRI has the lowest risks
Fluoxetine
Which antipsychotic is associated with GDM and weight gain
Olanzapine
Which antipsychotic can cause agranulocytosis in the fetus and breast fed infants
Clozapine
What should nitrofurantoin be avoided in the third trimester
Risk of neonatal haemolytic anaemia
What syndrome does chloramphenicol cause in the neonate as it can cross the placenta and is excreted in breast milk
Grey baby syndrome
