Pharmacology Flashcards
What is the half-life of fluoxetine?
5-7 days
The half-life of fluoxetine and its active metabolite norfluoxetine is respectively 2 to 4 days and 5 to 15 days, more extended than other SSRIs (approximately 1 day).
What is the half-life of quetiapine?
7-12 hours
What is the half-life of ziprasidone?
7-12 hours
What is the half-life of risperidone?
3 hours in extensive metabolisers
20 hours in slow metabolisers
What is the half-life of paliperidone?
24-28 hours
What is the half-life of olanzapine?
30 hours
What is the antipsychotic with the longest half-life?
Aripiprazole (72 hours/3 days)
What is the half-life of venlafaxine?
4 -5 hours
What is the half-life of diazepam?
Up to 100 hours
What is the half-life of oral risperidone (not it’s metabolite)?
3 hours
The half-life of oral risperidone is approximately 3 hours, while that for 9-hydroxyrisperidone is 24 hours.
What is the half-life of citalopram?
24-72 hours
Most SSRI’s besides fluoxetine have a half life of 24-72 hours
What is the half-life of lithium?
Approximately one day (18-35 hours)
Lithium is almost exclusively excreted via which system?
Renal
What is the half-life of metoclopramide?
5 hours
What is the half-life of valproate?
16 hours
Valproate is well absorbed with bioavailability close to 100%. It has a half-life of 16 hours and is 90% protein bound.
