Pharmacology Flashcards
What is the initial MOA of corticosteroids?
Bind intracellular receptors, receptor/ligand complex binds DNA to affect transcription
What are the 6 classes of steroid hormone?
Glucocorticoid, mineralocorticoid, progestin, oestrogen, androgen, vitamin D
What type of steroid hormone is cortisol?
Glucocorticoid
What is cortisol’s action on the CNS?
Mood lability, euphoria/psychosis, decreased libido
What is cortisol’s action on the bone/connective tissue?
Accelerates osteoporosis, decreased; serum calcium, collagen formation, wound healing
What is cortisol’s immunological actions?
Decreased; capillary dilatation/permeability, leucocyte migration, macrophage activity, inflammatory cytokine production
What is cortisol’s metabolic actions?
Increased blood sugar, increase lipolysis, central distribution, increased proteolysis
What is cortisol’s action on the CVS/renal system?
Increased CO, increased BP, increased renal blood flow and GFR
What are the 3 principles of use of corticosteroids?
Suppress inflammation, suppress immune system, replacement treatment
What are mineralocorticoid receptors located?
Kidneys, salivary glands, gut, sweat glands
What the the effects of aldosterone via MR?
Sodium/potassium balance, K+/H+ excretion, increased Na+ absorption, bp regulation, ECW regulation
What are the direct effects of corticosteroids on bone?
Reduction of osteoblast activity and lifespan, suppression of replication of osteoblast precursors, reduction in calcium absorption
What occurs in Paget’s disease?
Abnormal osteoclastic activity followed by increased osteoblastic activity, abnormal bone structure with reduced strength and increased fracture risk
What bones does Paget’s affect?
Long bones, pelvis, lumbar spine and skull predominantly
What does Paget’s present with?
Bone pain, deformity, deafness or compression neuropathies
