Pharmacology

Question 1

Aliskiren

Answer 1

Blocks enzymatic activity of renin

Question 2

Amiloride

Answer 2

Competitive inhibitor of ENaC in distal nephron. Potassium sparing

Question 3

Biguanides (metformin)

Answer 3

Inhibits liver gluconeogenesis; enhances insulin receptor signaling

Question 4

Eplerenone and Spironolactone

Answer 4

Mineralocorticoid receptor antagonist

Question 5

Sulfonylureas

Answer 5

Targets pancreatic Beta cells–insulin secretagogue

Question 6

Thiazolidenediones (Pioglitazone)

Answer 6

Insulin sensitizing agent–enhance the action of insulin in target cells

Question 7

Tolvaptan

Answer 7

V2 receptor antagonist

Question 8

Clomiphene

Answer 8

Selective estrogen receptor modulator (SERM); antagonizes hypothalamic pituitary ERalpha

Question 9

Luprolide

Answer 9

GnRH agonist

Question 10

Dexamethasone and Prednisone

Answer 10

glucocorticoid analogues

Question 11

Fludrocortisone

Answer 11

mineralocorticoid agonist

Question 12

Bromocryptine and cabergoline

Answer 12

dopamine receptor agonists; block PRL secretion. Bromocryptine also antagonizes GH secretion

Question 13

Octreotide

Answer 13

Somatostatin analogue; impaires GH secretion