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Dental Boards part 2 > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

azole = ?

A

azole-type antifungal drugs (eg Fluconazole)

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2
Q

coxib = ?

A

COX-2 inhibitors (Celecoxib)

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3
Q

dipine = ?

A

dihydropyridine calcium channel blockers (Nifedipine)

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4
Q

olol = ?

A

beta-adrenergic receptor blockers (Propranolol)

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5
Q

ilol or alol = ?

A

beta-adrenergic receptor blocker that ALSO blocks alpha1-adrenergic receptors (Carvedilol)

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6
Q

onium or urium = ?

A

quaternary ammonium compounds, usually competitive peripherally acting skeletal muscle relaxers (Pancuronium)

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7
Q

osin = ?

A

alpha1-adrenergic receptor blockers (Prazosin)

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8
Q

mab = ?

A

monoclonal antibodies (Infliximab)

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9
Q

pril or prilat = ?

A

angiotensin converting enzyme (ACE) inhibitors (Captopril)

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10
Q

sartan = ?

A

angiotensin II receptor blockers (Losartan)

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11
Q

statin = ?

A

HMG-CoA reductase inhibitor antilipid drugs (Lovastatin)

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12
Q

triptan = ?

A

serotonin 5-HT agonist antimigraine drugs (Sumatriptan)

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13
Q

What is intrinsic activity with respect to a graded dose-response curve?

A

The maximal effect of the drug

Agonists HAVE intrinsic activity
Antagonists have no intrinsic activity

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14
Q

How is affinity of a drug to a receptor measured?

A

Dissociation constant (Kd)

Lower Kd means high affinity

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15
Q

What is the therapeutic index of a drug?

A

The margin of safety for the drug

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16
Q

What are two important functions of drug metabolism?

A

1) Inactivation of the drug
2) making the drug more water soluble

when the drug is made active by metabolism, it’s called a Prodrug

17
Q

Which of the following is not part of a Phase 1 reaction of drug metabolism?

a) oxidation
b) conjugation
c) reduction
d) hydrolysis

A

b) conjugation

this is phase II where a chemical substituent is added to the drug

Most common conjugation rxn is glucuronide conjugation

18
Q

Which of the following is not caused by Prazosin?

a) Vasoconstriction
b) reduce afterload and preload
c) reduce contraction of smooth muscle in the sphincter and trigone muscles of the bladder
d) reduce contraction of the prostate

A

a) VasoDILATION

Dental Boards part 2 (4 decks)

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