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Psych > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

classes of antidepressants

A

TCA
MAOI
SSRI
Atypical antidepressants (SNRI, NDRI, SARI, NASA)

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2
Q

TCA

A 
Imipramine
Amitriptyline
Trimipramine
Nortriptyline
Desipramine
Clomipramine
Doxepin
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3
Q

Common side effects of TCA

A

Anti HAM
Anti-Histamine: sedation.
Anti-Adrenergic: Orthostatic hypotension, tachycardia, arrhythmias.
Anti-Muscarinic: Dry mouth, constipation, urinary retention, blurred vision, tachycardia.

Weight gain.
Lethal overdose

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4
Q

Major complications of TCA

A

Convulsions, coma, cardiotoxicity, avoid in pts with preexisting conduction abnormalities.

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5
Q

Mechanism of action MAOI

A

Prevent inactivation of biogenic amines, such NE, 5HT, Dopa, Tyramine.

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6
Q

MAO-A vs MAO-B

A

MAO-A: preferentially deactivates serotonin.

MAO-B: preferentially MAO-B preferentially deactivates NE/Epi

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7
Q

Common side effects of MAOI

A

Orthostatic hypotension, drowsiness, weight gain, sexual dysfunction, dry mouth, sleep dysfunction.

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8
Q

Serotonin syndrome

A

SSRI and MAOI taken together. Presents first as lethargy, restlessness, confussion, flushin, diaphoreiesis. May progress to hyperthermia, hypertonicity, rhado, convulsions and renal failure.

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9
Q

Hypertensive crisis

A

MAOI with tyramine rich foods or sympathomimetics. Cause a build up of stored catecholamines.

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10
Q

SSRI

A 
Fluoxetine
Setraline
Paroxetine
Fluvoxamine
Citalopram
Escitalopram
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11
Q

Side effects of SSRI

A

Sexual dysfunction, GI disturbances, insomnia, HA, anorexia.

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12
Q

Atypical antidepressants

A

SNRI Venlafaxine:
NDRIs Bupropion
SARIs: Nefazodone/Trazodone
NASA: Mirtazapine

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13
Q

Treatment of choice for refractory major depression and needs to gain weight

A

Mirtazapine

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14
Q

Smoke cessation

A

Bupropion, be careful it can

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15
Q

Low potency antipsychotics

A

Chlorpromazine

Thioridazine

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16
Q

High potency antipsychotics

A 
Haloperidol
Fluphenazine
Trifluoperaizne
Perphenazine
Pimozide.
17
Q

Side effect difference between low and high potency antipsychotics

A

Low potency have higher Anti HAM effects

High potency have more EPS

18
Q

Types of antidopaminergic s/e of traditional antipsychotics

A

Parkinsonism: mask like facies, cogwheel rigidity, pill rolling tremor
Akathisia: subjective anxiety, restlessness, fidgetiness.
Dystonia: sustained contraction of muscles of neck, tongue, and eyes.
Hyperprolactinemia: leads to decreased libido, galactorrhea, gynecomastia.

19
Q

Treatment of EPS (parkinsonism, akathisia, dystonia)

A

Amatandine, Benadryl, Benztropine.

20
Q

NMS “FALTER”

A

Fever, Autonomic instability, Leukocytosis, Tremor, Elevated CPK, Rigidity.

21
Q

Treatment NMS

A

Dantrolene, Bromocriptine, amantadine, and bromoctiptine

22
Q

Antipsychotics approved for treatment of mania

A

Quetiapine and Ziprasidone

23
Q

Mood stabilizers

A

Lithium
Carbamazepine
Valproic acid

24
Q

Side effects of Li

A

Hypothyroidism and Nephrogenic Diabetes Insipidus.

25
Q

Toxic levels of Li

A

AMS, coarse tremors, convulsions.

26
Q

Indications for Carbamezapine

A

Mixed episodes
Rapid-cycling bipolar disorder
Trigeminal neuralgia

27
Q

Side effects of Carbamezapine

A

Leukopinia, hyponatremia, aplastic anemia, and agranulocytosis.

28
Q

Indications for Valproic acid

A

mixed manic episodes and rapid cycling bipolar disorder

29
Q

Side effects of Valproic acid

A

Hepatotoxic, thrombocytopnea, weight gain and sedation

30
Q

Long acting (1-3 days) benzos

A

Chlordiazepoxide (Librium): EtOH detox, presurgery anxiety

Diazepam (Valium): rapid onset, tx anxiety and seizure control

Flurazepam (Dlamane): rapid onset, treats insomnia

31
Q

Intermediate acting (10-20 hours) benzos

A

Alprazolam (Xanax): treats panic attacks
Clonazepam (Klonopin): treats panic attacks, anxiety
Temazepam (Restoril) treats insomnia

Psych (4 decks)

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