Pharmacology Flashcards
Perfusion Therapies
Reduces fluid volume in the vessels.
- Diurectics
- furosimide (Lasix)
- Hydrochlorithiazide
- Bumetanide
- Triamterene
- Spironolactone
- Metolazone
~Considerations:
- Monitor Serum Electolyte Levels
- Weight
- Hydration Status
- Monitor Breath Sounds
Blocks a potent natural vasoconstrictor, Angiotensin II
ACE Inhibitors & Angiotensin Inhibitors
- Benazepril
- Captopril
- Lisinopril
- Losartan
- Valsartan
- Considerations
- Vital sign changes
- First dose may cause severe hypotension, monitor BP
- BP if given intravenously (IV) and with any changes in LOC
- Assess for angioedema (life threatning)
- Monitor CBC for Neutropenia or agranulocytosis
6.
Contain a diuretic, usually a potassium-sparing diuretic, and another class of drugs such as adrenergic agents or ACE Inhibitors.
Combination Drugs
- ** **Hydochlorithiazide combos:
- Propranolol
- Metoprolol
- Timolol
- Bisoprolol
~Considerations:
- Serum Electrolyte Levels
- weight
- breath sounds
- hydration status
Cause dilation of blood vessels
Vasodilators
- Diazoxide
- hydralazine
- minoxidil
- nitroprusside
Considerations:
- may produce reflex tachycardia
- may produce angina in pt. with Coronary Artery Disease
- monitor Na & H2O retention
- Nitroprussides
- Drug of choice for hypertensive emergency
- Avoid dropping BP too quickly
- Metabolizes to cyanide, careful monitoring required
4.
Blocks beta1 -adrenergic receptors in heart
Blocks alpha1 -adrenergic receptors in arterioles
Stimulates alpha2 receptors in brainstem and/or blocking peripheral adrenergic neurons.
Adrenergic Antagonist
- beta-blockers: atenolol, metoprolol
- alpha1 -antagonist: doxazosin, prazosin
- alpha2 -antagonist: clonidine, methyldopa
- adrenergic neuron blockers: guanadrel, resperine
Considerations:
- Vital signs
- Hold med. if HR< 60 bpm or BP< 90/60mm Hg
- Use care ambulating, monitoring for othrostatic hypertension
- Monitor diabetics for hypoglycemia
Calcium-Channel Blockers
Treats angina, dysrythmias, & hypertension, reducing calcium, muscular contractility, peripheral vascular resistance, & BP
- Nifedipine
- Verapamil
- Diltiazem
Considerations:
- Obtain baseline ECG, HR, & BP before starting meds
- Educate importance of daily BP log & compliance
- Contraindictated in pt. with third-degree block of sick sinus syndrome
- Tachycardia & Hypotension if IV
- Patient should avoid grapefruit juice
*
Prehypertension
120-139mm Hg Systolic
or
80-89mm Hg Diastolic
Hypertension
Stage 1: 140-159mm Hg Sysyolic or 90-99mm Hg Diastolic
Stage 2: >/= 160 Systolic or >/= 100mm Hg Diastolic
enotes the average pressure in the arterial circulation throughout the cardiac cycle
Mean Arterial Pressure (MAP)
the force exerted against the walls of the arteries by the blood as its pumped from the heart
Blood Pressure
Factors that influence BP
- Sympathetic Nervous System (SNS) Stimulation
- Circulating Epinephrine & noreponephrin
- Renin-Angiotensin-Aldosterone System-responds to renal perfusion
- Local Factors
Systolic Pressure > 180 mm Hg
Diastolic Pressure> 120 mm Hg
Hypertension Emergency
- immediate treatment (within 1 hour)
List some Modifiable Risk Factors for Hypertension
- High Na intake
- Low Potassium, Calcium, & Mg intake
- Obesity
- Excess alcohol consumption
- Insulin resistance
List some Nonmodifiable Risk Factors for Hypertension
- Genetic Factos
- Age
- Family History
- Race
Hypertension Crisis
Manifestations
- Rapid onset
- Blurred Vision
- Papilledema
- 180/120 mm Hg
- Headache, confusion, motor & semsory deficits
** Interventions:**
- ** **Administer medication: vasodilators, calcium-blockers,
- BP lowered gradually with constant monitoring
- Reduce pt. anxiety
1.