Pharmacology

Question 1

Ocreotide is an example of what drug?

Answer 1

Somatastatin analogue

Question 2

HIT is caused by development of antibodies against what?

Answer 2

Platelet factor 4 and heparin

Question 3

How long does it take for HIT to develop?

Answer 3

5-10 days after the initiation of treatment

Question 4

What is the mechanism of action of allopurinol?

Answer 4

Xanthine oxidase inhibitor

Question 5

What are the most severe adverse effects to look out for with allopurinol?

Answer 5

If the patient develops a rash this could be SJS, TEN, DRESS syndrome or SCAR and so must be stopped immediately

Question 6

Individuals with which allele are more likely to have adverse affects with allopurinol?

Answer 6

HLA-B*5801

Question 7

Why is it not recommended to co prescribe nicorandil and sildenafil?

Answer 7

The action of sildenafil is vasodilation, allowing increased blood flow to the penis. Nitrates and nicorandil also cause vasodilation therefore this can lead to a large drop in blood pressure.