Pharmacology

Question 1

Omeprazole

Answer 1

• proton pump inhibitor
Impairs H+/K+ ATPase irreversibly

= new pumps need to be made for acid production

Question 2

Ranitidine/famotidine/cimetidine

Answer 2

H2-receptor antagonist

Competitively blocks H2 receptor on parietal bells

Efficacy depends on maintaining plasma concentratio

Question 3

Contraindication and side effects for furosemide use

Answer 3

Contraindications:
hypokalemia
- hyponatremia
- dehydration

Side effects:
- worsening of ARF
-

Question 4

Furosemide: Mechanism of action

Answer 4

Loop diuretic, Natriuretic
inhibits Na+-K+-2Cl− cotransporter in the ascending limb of the loop of Henle

Changes in renal hemodynamics: increase in renal blood flow and possibly GFR, increase of PGE2 production in ascending loop of Henle

Changes in systemic hemodynamics: e.g. increase in stroke volume and cardiac output