Pharmacology

Question 1

agonist

Answer 1

A compound that binds to and activates a receptor - produce response

Question 2

antagonist

Answer 2

A compound that reduces the effect of an agonist at a receptor - block response

Question 3

competitive antagonist

Answer 3

binds to the same sight as agonist and competes for binding

Question 4

non-competitive antagonist

Answer 4

binds to a site different from agonist site and induces a conformational change which restricts binding

Question 5

partial agonist

Answer 5

A low efficacy agonist that is unable to elicit the maximal response from a receptor, irrespective of the concentration applied

Question 6

affinity

Answer 6

A measure of the equilibrium constant of the reversible reaction between a drug (agonist or antagonist) and a receptor - strength of binding

Question 7

efficacy

Answer 7

A measure of the magnitude of the (cellular) response produced when an agonist binds to a receptor - ability to evoke cellular response

Question 8

potency

Answer 8

A measure of the concentration of a drug at which it produces an effect of a given magnitude

Question 9

agonist mechanism

Answer 9

agonist binds to receptor resulting in activation which generates a response

Question 10

antagonist mechanism

Answer 10

binds to the receptor but fails to activate it so no response is generated

Question 11

agonists possess

Answer 11

affinity and efficiancy

Question 12

antagonists possess

Answer 12

affinity only