Pharmacology

Question 1

Which adverse effects are associated with loop diuretics?

Answer 1

Hypotension, hyponatraema, hypokalaemia hypomagnasaemia, hypochloraemic alkalosis, ototoxicity, hypocalcaemia, renal impairment, hyperglycaemia, gout

Question 2

What is the mechanism of action of a statin?

Answer 2

Inhibits HMG-CoA reductase (rate limiting enzyme in hepatic cholesterol synthesis)

Question 3

What is the mechanism of action of clopidogrel?

Answer 3

Antagonist of P2Y12 adenosine diphosphate receptor

Question 4

Which drug interaction is seen between clopidogrel and PPIs?

Answer 4

Reduced efficacy of clopidogrel

Question 5

Which adverse signs are seen in peri-arrest tachycardia?

Answer 5

Shock
(Hypotension <90mmHg SBP, pallor, sweaty, clammy, cold extremities, confusion, impaired consciousness)
Syncope
MI
Heart failure

Question 6

How is a tachycardia with adverse signs managed?

Answer 6

Synchronised DC shock - up to 3

Question 7

What is an acceptable K+ level once starting an ACEi?

Answer 7

Up to 5.5 mol/l