Pharmacology Flashcards
1
Q
High Volume of Distribution
A
Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L)
A drug with a high Vd has a propensity to leave the plasma and enter the extravascular compartments of the body, meaning that a higher dose of a drug is required to achieve a given plasma concentration. (High Vd -> More distribution to other tissue)
2
Q
Low Volume of Distribution
A
Volume of Distribution (L) = Amount of drug in the body (mg) / Plasma concentration of drug (mg/L)
A drug with a low Vd has a propensity to remain in the plasma meaning a lower dose of a drug is required to achieve a given plasma concentration. (Low Vd -> Less distribution to other tissue)
