Pharmacology

Question 1

Which HLA-B variant is associated with increased risk of SJS/TEN in carbamazepine treatment?

Answer 1

HLA-B*15:02

Question 2

Which ethnic group/region is HLA-B*15:02 mutation prevalent in?

Answer 2

Han Chinese (36%), higher prevalence in Oceania, East Asia, Central/South Asia

Question 3

Abacavir hypersensitivity reaction

Answer 3

HLA-B*57:01
4-8% of patients with HIV-1 within first 6 weeks of starting abacavir

Question 4

Symptoms of abacavir hypersensitivity reaction

Answer 4

Fever
Rash
Abdominal pains
Lethargy
Improved within 72h of discontinuing drug