Oncology

Question 1

Most common gene aberration in clear cell renal cell carcinoma

Answer 1

von Hippel-Lindau gene (50-90% of ccRCC)

Question 2

Subtypes of renal cell carcinoma

Answer 2

Clear cell (75%)
Non-clear cell (25%)
- papillary type 1 (5%)
- papillary type 2 (10%)
- chromophobe (5%)
- oncocytoma (5%)

Question 3

Cisplatin ineligibility global consensus definition (5 things)

Answer 3

ECOG 2 or more
CrCl <60ml/min
Grade 2 or more hearing loss (hearing loss but hearing aid not indicates)
Grade 2 or more neuropathy (moderate symptoms, limiting instrumental ADLs)
NYHA Class III or more heart failure