PHARMACOLOGY

Question 1

Which Eicossanoid promotes production of aldosterone

Answer 1

12-HETE

Question 2

Which group of hormones inhibit all Eicossanoid synthetic pathways

Answer 2

Corticosteroids

Question 3

How do corticosteroids inhibit all Eicossanoid synthesis pathways

Answer 3

Stimulating synthesis of inhibitory proteins called Annexins or Lipoxins

Question 4

How else do corticosteroids inhibit eicosanoid syntesis

Answer 4

Inhibit PLA2 activity possibly by interfering with phospholipid binding preventing AA release

Question 5

What is zileuton

Answer 5

A 5-LOX inhibitor

Question 6

What is zafirlukast

Answer 6

A CYSLTR inhibitor

Question 7

What indication is treated using zileuton and zafirlukast

Answer 7

Asthma

Question 8

Which serotonin agonist is used as a non-benzodiazepin anxiolytic

Answer 8

Buspirone

Question 9

Which serotonin agonist is used as a appetite suppressant

Answer 9

Dexfenfluramine

Question 10

What are sumatripan and congeners and their functions

Answer 10

Serotonin agonists effective against migraine and cluster headaches

Question 11

what drug categories are the first line of severe migraine attacks

Answer 11

Triptans

Question 12

which drugs are the most used anti-depressants

Answer 12

SSRIs

Question 13

Which enzyme generates prostanoids mainly for house keeping functions

Answer 13

COX-1

Question 14

Which enzyme generates prostanoids for inflammation and cancer

Answer 14

COX-2

Question 15

Endothelial COX-2 is the primary source of?

Answer 15

Vascular prostacyclin(PGI-2)

Question 16

state 4 none selctive COX inhibitors

Answer 16

Indomethacin, sulindac, meclofenamate, ibuprofen

Question 17

What are the active precursors of kallikreins

Answer 17

zymogens

Question 18

which enzyme is identical to Angiotensin converting enzyme

Answer 18

Kininase II

Question 19

which two substances are almost completely hydrolyzed during a single passage through pulmonary vascular bed

Answer 19

Angiotensin I and Bradykinin

Question 20

which enzyme is activated by kinin agonists

Answer 20

phospholipase C

Question 21

Under what conditions is B2 kinin receptor upregulated

Answer 21

Under inflammatory conditions

Question 22

Activity of RAAS is determined by?

Answer 22

Renin secretion rate

Question 23

Effects of angiotensin II on renin release

Answer 23

Inhibitory

Question 24

what is the ACE2-Corona virus association

Answer 24

ACE2 binds SARSCOV2 facilitating its entry into the cells

Question 25

which enzyme converts nitroglycerine to NO

Answer 25

Mitochondrial aldehyde reductase