MYCOLOGY Flashcards
What is the MOA of sordarins
Inhibit fungal protein synthesis
Which drugs inhibit fungal microtubule synthesis
Griseofulvin
Name a fungal nucleic acid synthesis inhibitor
5-flucytosine
Name 3 classes of fungal cell wll inhibitors
Nikkomycin, Echinocandins, Polyoxins
Name 3 classes of fungal ergosterol inhibitors
Allyamines, Azoles, Polyenes
What enzume is targeted by allylamines
Squalene epoxidase
Which antifungal agent is resisted by production of catalse and hyperoxide dismutase
Amphotericin B
which fungus resists AMB in this way
Aspergillus fumigatus
Cholestrol importation is a mode of resistance againsts which antifungal agents
Azoles
Wich fungs exhibits cholestrol importation
Aspergillus fumigatus
How can you reduce toxicity of AMB
Combination with flucytosine
incorporation into liposomes (liposomal AMB)
What disease do yeast cause when there is T-Cell deficiency
chronic Mucocutaneous candidiasis (CMC)
Which drugs are used in treatment of superficial candida infections
Azole preperations, nystatin
Which drugs are used in treatment of disseminated Candida infections
Fluconazole, AMB, Flucytosine
what is the CRAG test and what does it detect
it is Cryptococcal antigen tests (latex agglutination test) which detects polysaccharide capsule antigen
