Pharmacology Flashcards
Simple diffusion is dependent on
Lipid solubility
Ionization
Molecular weight
Absorption of most compounds is by which method?
Simple diffusion
Facilitated passive diffusion transports molecules by
A carrier that moves along a compound with the concentration gradient
What is the main transport method for glucose
Facilitated passive diffusion
What time of type of compounds rely on active transport for absorption?
Those mimicking endogenous compounds
Define pinocytosis
Transport accomplished by compounds being engulfed and packaged by a cell, requires energy
Define compound distribution
Movement of drugs from an intravascular space during extravascular tissue
What factors influence distribution?
Rate of blood flow Drug ability to bind to tissues Permeability of cell membranes pH Protein binding ability Drug composition Body compartments
What is the formula to define the volume of distribution?
Total amount of drug in the body (mg)/
plasma concentration of drug (mg/L) x weight (kg)
A drug with a large volume of distribution has
Distribution to many tissues
Drug with a long half life
A drug with a small volume of distribution
Tends to have highly protein bound drugs
Premature infants have a _______ volume of distribution compared with term infants
Higher
Protein bound drugs are
Bound to protein in plasma
Only active when unbound
Among protein bound drugs, acidic drugs typically bind to
Albumin
Among protein brown drugs, basic drugs typically bind to
Alpha glycoproteins
Lipoproteins
