Pharmacologic Treatment Of Osteoporosis Flashcards
MOA of raloxifene
It is a selective estrogen receptor modulator. It is a partial agonist of estrogen in bone and antagonist in breast in and endometrium
Optimal intake of calcium for postmenopausal women not on estrogen 50-65 yo, and those that are on estrogen 50-65 yo
On estrogen = 1000 mg/day
Not on estrogen = 1500 mg/day
MOA of bisphosphonates
Inhibit osteoblasts conversion to osteoclasts
What medication can cause osteonecrosis of the jaw
Bisphosphonates
How should bisphosphonates be taken to prevent esophagitis
Take with 8oz of water 40 min before eating in an upright position
Optimal intake of calcium for premenopausal women, 25-50 yo
1000 mg/day
Recommended doses of Vitamin D
400 - 800 IU daily
Optimal intake of calcium for teenagers 11-24 years
1200 - 1500 mg/day
Optimal intake of calcium for men and women >65yo
1500 mg/day
Route of administration of calcitonin
SQ/IM injection or nasal spray
3 main side effects of estrogen treatment
- DVT
- Endometrial cancer
- Breast cancer
Optimal intake of calcium for birth to 6 months old
400 mg/day
MOA of teriparatide
It is a recombinant form of PTH which stimulates bone formation
MOA of estrogen in treatment of osteoporosis
Suppresses IL-6 secretion, inhibits osteoclasts, decreases bone resporption, increases calcium absorption
Prevention dose vs treatment dose when using alendronate (fosamax)
Prevention = 5mg/day Treatment = 10mg/day
