pharmacokinetics & pharmacogenomics

Question 1

bioavailability equation

Answer 1

F = (AUCe / AUCi) x (dosei / doseE) x 100

Question 2

Vd equation

Answer 2

Vd = amount in body / concentration in plasma

Question 3

Cl equation

Answer 3

(F x dose) / AUC
ke x Vd

Question 4

Ke equation

Answer 4

Cl / Vd

Question 5

predicting drug concentration equation

Answer 5

Ke = [ln(C1/C2)] / t

Question 6

half life equation

Answer 6

0.693 / ke

Question 7

loading dose equation

Answer 7

(desired concentration x Vd) / F

Question 8

what is zero order kinetics

Answer 8

amount of drug removed remains constant

Question 9

what is first order kinetics (MOST DRUGS)

Answer 9

percent of drug removed remains constant

Question 10

which drugs follow michaelis menten kinetics

Answer 10

phenytoin
theophylline
voriconazole

Question 11

what genetic testing does abacavir require

Answer 11

HLA B 5701

Question 12

what genetic testing does allopurinol require

Answer 12

HLA B 5801

Question 13

what drugs require HLA B 1502 testing

Answer 13

carbamazepine
oxcarbazepine
phenytoin
fosphenytoin

Question 14

what genetic testing does clopidogrel require

Answer 14

CYP2C19*2 and *3

Question 15

what genetic testing does warfarin require

Answer 15

CYP2C9 and VKOR1

Question 16

what genetic testing does codeine require

Answer 16

CYP2D6 URM