Pharmacokinetics Of Spinal Anesthesia

Question 1

How do you make equal parts of Tetracaine 1% and Dextrose 10% to make the solution hyperbaric?

Answer 1

1. Need to use preservative free 50% dextrose bristojet
2. Dilute 1mL of 50% dextrose with 4mL of sterile preservative free saline in 5ml syringe
3. This gives you 5mL of 10% dextrose solution
4. For 1.4 mL of Tetracaine add 1.4 mL of dextrose solution

Question 2

Which baricity is commonly used?

Answer 2

Hyperbaric solutions are most commonly used.

Question 3

Which baricity of LA solution offers a more profound block and prolonged duration of action?

Answer 3

Your isobaric solution (bupivacaine 0.5% as it is used at South Jersey)

Question 4

What is baricity?

Answer 4

Baricity is the ratio of the density of the local anesthetic to the density of the CSF at a specific temperature.