Pharmacokinetics Of Drugs Flashcards
E
Draw Omeprazole and fluconazole. What type of substrates are they in CYP2C9 and why?
Type II substrates of CYP450 system because they inhibit the enzyme and keep the Fe3+ in planar ring which means the haem-thiolate structure is kept in place and cannot generate energy (going from hexa to petal configuration).
What heteroatoms are commonly seen in type II substrate for CYP450
Nitrogen and soulful as they are able to stabilise the Fe3+ in planar position because they can share electrons .
Why is nitrogen stable ?
The arrangement of the eight atoms of sulphur in a crown structure minimises the interelectronic repulsions between the lone pairs, thus increasing the stability of the molecule. Sulfur is less electronegative than oxygen (2.4 and 3.5, respectively) and as a consequence bonds to sulfur are less polar than the corresponding bonds to oxygen. https://ysjournal.com/chemistry/why-is-octasulphur-the-most-stable-form-of-sulphur/
Why is nitrogen triple bond more stable than double ?
The dinitrogen molecule (N2) is an “unusually stable” compound, particularly because nitrogen forms a triple bond with itself. This triple bond is difficult hard to break. https://chem.libretexts.org/Bookshelves/Inorganic_Chemistry/Supplemental_Modules_and_Websites_(Inorganic_Chemistry)/Descriptive_Chemistry/Elements_Organized_by_Block/2_p-Block_Elements/Group_15%3A_The_Nitrogen_Family/Z007Chemistry_of_Nitrogen(Z7)
