Pharmacokinetics III Flashcards
1
Q
How do you calculate therapeutic index?
A
TD(50) / ED(50)
2
Q
What is likely to happen in a drug interaction with a weakly bound drug?
A
A negligible difference in unbound drug leading to minimal patient harm (if any)
3
Q
What is likely to happen in a drug interaction with a strongly bound drug?
A
Highly likely to cause patient harm
4
Q
What might be the reasons for a mismatch in individual data to population data? (3)
A
Concurrent drug therapy
Compliance issues
Malabsorption
5
Q
How do you assess patient renal function?
A
Creatinine as it is filtered through the kidneys relatively unchanged
6
Q
Name FIVE drugs which need to be monitored
A
Sodium Valproate Gentamycin Digoxin Methotrexate Ciclosporin
