Pharmacokinetics I Flashcards
1
Q
Write the equation for absolute bioavailability
A
F(route) = AUC (route) / AUC (IV)
2
Q
What is the one compartment model?
A
Assumption that the drug is distributed throughout the body in a single homogenous compartment
3
Q
Outline the two compartment model (2)
A
The assumption that the drug is distributed into two compartments
One central compartment and one peripheral compartment
4
Q
How do you calculate the volume of distribution?
A
Vd = mass of drug in the body / Cp
5
Q
How do you calculate the loading dose?
A
Loading dose = Cp x Vd
6
Q
Write the equation for a zero order reaction
A
Cp(t) = -K(0)t + Cp (0)
7
Q
Write the equation for a first order reaction
A
ln(Cpt) = ln(Cp0) - Kt
