pharmacokinetics

Question 1

half-life

Answer 1

Time it takes to reduce the plasma concentration by 50%

Question 2

first-pass metabolism

Answer 2

Drugs absorbed from the gut are delivered directly to the liver via the portal vein
Drugs that undergo hepatic metabolism will be degraded prior to reaching their site of administration

Question 3

bioavailability (F)

Answer 3

Fractional extent to which a dose of a drug reaches its site of action; how much of the dose is actually available
Oral F is usually 50%
IV F is usually 100%