Pharmacokinetics

Question 1

The chemical structure of MDMA allows it to reach the brain quickly after ingestion

Question 2

MDMA is not fully absorbed from the stomach into the bloodstream

Answer 2

Instead, the MDMA molecules get emptied from the stomach into the small intestine.

Thereafter, MDMA diffuses into the vascular system

Question 3

How is MDMA metabolised?

Answer 3

Mainly by: Liver- heart- lungs- heart- brain

Question 4

MDMA is readily absorbed from what?

Answer 4

The intestinal tract

Question 5

When MDMA is absorbed from the intestinal tract, where does it reach its peak and when?

Answer 5

In the plasma, about 2 hours after oral administration

Question 6

In the liver Cytochrome P450 specifically CYP2D6 initiated metabolic breakdown. However there are a complex array of different enzymes involved in metabolic action. Enzyme response is saturated and CYPD2D6 is not as abundant, therefore, increases of the drug can dramatically change levels of toxicity for individuals

Question 7

What is the speed of the elimination of MDMA from the body?

Answer 7

Moderately slow

Cmax half life is 8 hours (takes about 5 half lives to eliminate 95% of the drugs therefore it takes about 40 hours of MDMA to be cleared from the body