How Does Mdma Interacf With Neurons?

Question 1

How does MDMA work at a synaptic level?

Question 2

MDMA IS A SYNTHETIC PSYCHEDELIC

Answer 2

First synthesised in 1912 by Anton Kollisch. Known to induce euphoria and increased sociability.

Question 3

MDMA INDICATIONS

Answer 3

PTSD, Autism, Obesity, Narcolepsy and ADHD

Question 4

MDMA MECHANISM OF ACTION

Answer 4

Increases reputable and release of serotonin and norepinephrine. Increased oxytocin release may also play a role.

Question 5

How does MDMA interact with neurone?

Answer 5

1) MDMA increases the net release of these neurotransmitters from their respective axon terminals:

Serotonin
Noradrenaline
Dopamine

2) MDMA binds to, thus blocking, the transporter involved in its reuptake

Question 6

MDMA increases the net release of which neurotransmitters?

Answer 6

Serotonin
Noradrenaline
Dopamine

Question 7

MDMA binds to and thus blocks what?

Answer 7

The transporter involved in its reuptake

Question 8

Serotonin axons begin where?

Answer 8

In the brain stem

Question 9

Serotonin axons are connected to what areas of the brain?

Answer 9

All areas

Question 10

MDMA causes the serotonin neurons to release what? Stored where?

Answer 10

Large amounts of serotonin which are stored in the axon terminals

Question 11

What is responsible for the primary subjective effects of MDMA?

Answer 11

The substantial serotonin release

Question 12

What regions of the Brain are affected by ecstasy?

Answer 12

Neocortex
Hypothalamus
Basal Ganglia
Amygdala
Hippocampus