Pharmacokinetics Flashcards

1
Q

Bioavailability factors

A

route of administration,drug enters the systemic circulation, conc appearing in the plasma is entered over time to say area under the curve

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2
Q

Extraction or extraction ratio

A

fraction or percentage of drugs being removed from the perfusing blood during its passage through the organ

If it’s high, bioavailability is low

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3
Q

dosage regimen

A

plan for drug administration so that therapeutic levels remain in the blood without exceeding the minimum toxic concentration
ideally used with knowledge of both therapeutic conc and minimum toxic concentrations

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4
Q

Maintenance Dosage:

A

Because the maintenance rate=rate of elimination at a steady state

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5
Q

Maintenance Dosage

A

bioavailability

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6
Q

Loading Dose(if therapeutic concentration must be given rapidly)

A

Vd multiplied with desired concentration divided by bioavailability

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7
Q

therapeutic window

A

safe range between between minimum therapeutic concentration and minimum toxic concentration

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8
Q

theophylline

A

therapeutic concentration range of 8-20 mg/L but maybe toxic at concentration of more than 15-20 mg/L therapeutic window=8-16 mg/L

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9
Q

Corrected Dosage

A

100 mL/min

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10
Q

In elderly patients

A

72xScr

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