Pharmacokinetics

Question 1

What is pharmacokinetics?

Answer 1

Movement of drug into and out of body

Question 2

What are the functions we have( in vensim)

Answer 2

Step function
Pulse function
Pulse train function

Question 3

What are the characteristics of the Step Function.

Answer 3

Drug administration::::::
Not always constant
Do not always start at time zero

Question 4

Pulse function characteristics

Answer 4

Bolus injections
Single large dose delivered over a short period of time
INGESTING a single LARGE dose

🤪NOT REPEATED🤪
Dose=height×duration

Question 5

What are the characteristics of a pulse train function

Answer 5

Series of bolus injections

Repeated single large doses delivered over short periods

INGESTING a single dose of drugs at regular intervals

NB…consistent time between doses.

Question 6

What are the characteristics of CLEARANCE?

Answer 6

Allows us to use conc. Of drug instead of an absolute amount of drug
FOS elimination

It has a constant value

Clearance=Rate constant (k) ×Volume of distribution (V)

Question 7

Define clearance

Answer 7

The rate of elimination divided by the plasma concentration of the drug.

REMAINS CONSTANT SO THAT THE DRUG INPUT EQUALS THE DRUG OUTPUTS.

UNIT::::::::::: Volume/Time

Question 8

How many half-lives does it take to achieve a steady-state plasma drug concentration???

Answer 8

It takes Five (5) half lives