Pharmacogenomics

Question 1

G6PD - name

Answer 1

glucose 6 phosphate dehydrogenase

Question 2

G6PD - function

Answer 2

X-linked enzyme whose product protects RBC from oxidation

Question 3

G6PD result of mutation

Answer 3

can’t protect RBC’s from oxidation, hemolysis

Question 4

NAT - name

Answer 4

N-Acetyl Transferase

Question 5

NAT - substrate

Answer 5

isoniazid (TB treatment)

Question 6

NAT mutations

Answer 6

slow or fast acetylators, affect therapeutic dosage

Question 7

CYP3 - name

Answer 7

cytochrome P3 - comprises 40% of CYT450 monooxygenases

Question 8

CYP3 - substrates

Answer 8

cyclosporine

Question 9

CYP3 - inhibitors

Answer 9

grapefruit juice, ketocanazole

Question 10

CYP3 activators

Answer 10

rifampcin

Question 11

CYD2D6 - substrates

Answer 11

tricyclic antidepressants

Question 12

CYD2D6 - inhibitors

Answer 12

quinidine, fluoxetine

Question 13

CDY2D6 - what it activates

Answer 13

codine

Question 14

CYP2C9 - substrate

Answer 14

warfarin

Question 15

VOKRC1 - what it does

Answer 15

promotes prothrombin production

Question 16

G6PD - specific disease to avoid

Answer 16

anti-malarial drugs - they oxidize, and G6PD deficient individuals can’t protect RBC’s, leading to hemolysis