Pharmacogenomics Flashcards
1
Q
G6PD - name
A
glucose 6 phosphate dehydrogenase
2
Q
G6PD - function
A
X-linked enzyme whose product protects RBC from oxidation
3
Q
G6PD result of mutation
A
can’t protect RBC’s from oxidation, hemolysis
4
Q
NAT - name
A
N-Acetyl Transferase
5
Q
NAT - substrate
A
isoniazid (TB treatment)
6
Q
NAT mutations
A
slow or fast acetylators, affect therapeutic dosage
7
Q
CYP3 - name
A
cytochrome P3 - comprises 40% of CYT450 monooxygenases
8
Q
CYP3 - substrates
A
cyclosporine
9
Q
CYP3 - inhibitors
A
grapefruit juice, ketocanazole
10
Q
CYP3 activators
A
rifampcin
11
Q
CYD2D6 - substrates
A
tricyclic antidepressants
12
Q
CYD2D6 - inhibitors
A
quinidine, fluoxetine
13
Q
CDY2D6 - what it activates
A
codine
14
Q
CYP2C9 - substrate
A
warfarin
15
Q
VOKRC1 - what it does
A
promotes prothrombin production
