Pharmacogenetics

Question 1

NAT2 acetylate which type of drug?

Answer 1

isoniazid

Question 2

What drugs were used to study the CYP2D6?

Answer 2

Antihypertensive Debrisoquine and Oxytoxic Sparteine

Question 3

Conversion of codeine to morphine is metabolized by which protein?

Answer 3

CYP2D6

Question 4

Methylation of 6-mercaptopurine and azathipurine is catalyzed by which enzyme?

Answer 4

Thiopurine s-methyltransferase (TPMT)

Question 5

Warrfarin is is metabolized by which protein?

Answer 5

CYP2C9

Question 6

Wafarin is an analog of Vitamin K hence it binds to which enzyme?

Answer 6

VKORC1

Question 7

What is the role of G6PD?

Answer 7

Protects RBC from oxidative injuries due to radicals.

Question 8

Patient has G6PD deficiency. Which drugs and food may lead to hemalysis?

Answer 8

sulfamides, chloramphenicol, anitmalaria, and fava beans

Question 9

Malignant Hyperthermia is due to a defect in which protein? Describe the mechanism and the drug used.

Answer 9

Autosomal dominant, defect in RYR1 gene leading to unregulated Ca2+ release. Drugs: Dantrolene.

Question 10

What are the two tests for Malignant Hyperthermia?

Answer 10

1. Caffeine-halothane muscle contraction test

2. Genotype for CYP2D6