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Physiology & Pharmacology > ANS drugs, target, and mechanims > Flashcards

ANS drugs, target, and mechanims Flashcards

1
Q

What pathway does Alpha-1 activate

A

Gq

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2
Q

Activating Alpha-1 receptor leads to what response to the eye and what muscle?

A

Pupil dilation via radial muscle

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3
Q

What pathway does Alpha-2 activate

A

Gi

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4
Q

Alpha-1 pathway activates what G and what’s the response to vascular?

A

Gq and vasoconstriction

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5
Q

Response of alpha-1 on GI spinchter

A

Constriction

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6
Q

What are the TWO specfic Alpha-1 antagonists?

A

Prazosin

Tamsulosin

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7
Q

What are the TWO Alpha-1 agonists (activators)?

A

Phenylephrine

Oxymetazoline

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8
Q

What drugs activate both alpha-1 and 2?

A

Oxymetazoline

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9
Q

What TWO drugs inhibit both alpha-1 and 2?

A

Phenoxybenzamine

Phenotolamine

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10
Q

Name the beta-2 agonist?

A

Albuterol

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11
Q

What is a non selective vs. selective beta blocker?

A

Nonselective: Propanolol
Selective: atenolol

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12
Q

What is the (specific) alpha-2 agonist?

A

Clonidine

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13
Q

What is the mechanism of Beta-1 and 2?

A

Gs

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14
Q

Name the two CA storage inhibitors

A

Amphetamine

Pseudoephredine

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15
Q

Name the two CA re-uptake inhibitors

A

Cocaine and Imipramine

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16
Q

Name the one CA metabolism inhibitor

A

Iproniazid

17
Q

What is the mechanism if botox?

A

Prevents the release of Ach from the preganglionic neuron

18
Q

Name the four reversible AchE inhibitors

A

Neostigmine
Physostigmine
Pyrodostigmine
Edrophonium

19
Q

Name the one irreversible AchE inhibitors

A

Malathion

20
Q

What is the NMJ Nicotinic agonist?

A

Succinylcholine

21
Q

What is the NMJ Nicotinic antagonist?

A

Pancuronium

22
Q

Name the four muscarinic agonists

A

Acetylcholine
Pilocarpine
Methacholine
Bethanechol

23
Q

Beta-1 agonist

A

Dobutamine

Physiology & Pharmacology (2 decks)

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