ANS drugs, target, and mechanims Flashcards
What pathway does Alpha-1 activate
Gq
Activating Alpha-1 receptor leads to what response to the eye and what muscle?
Pupil dilation via radial muscle
What pathway does Alpha-2 activate
Gi
Alpha-1 pathway activates what G and what’s the response to vascular?
Gq and vasoconstriction
Response of alpha-1 on GI spinchter
Constriction
What are the TWO specfic Alpha-1 antagonists?
Prazosin
Tamsulosin
What are the TWO Alpha-1 agonists (activators)?
Phenylephrine
Oxymetazoline
What drugs activate both alpha-1 and 2?
Oxymetazoline
What TWO drugs inhibit both alpha-1 and 2?
Phenoxybenzamine
Phenotolamine
Name the beta-2 agonist?
Albuterol
What is a non selective vs. selective beta blocker?
Nonselective: Propanolol
Selective: atenolol
What is the (specific) alpha-2 agonist?
Clonidine
What is the mechanism of Beta-1 and 2?
Gs
Name the two CA storage inhibitors
Amphetamine
Pseudoephredine
Name the two CA re-uptake inhibitors
Cocaine and Imipramine
Name the one CA metabolism inhibitor
Iproniazid
What is the mechanism if botox?
Prevents the release of Ach from the preganglionic neuron
Name the four reversible AchE inhibitors
Neostigmine
Physostigmine
Pyrodostigmine
Edrophonium
Name the one irreversible AchE inhibitors
Malathion
What is the NMJ Nicotinic agonist?
Succinylcholine
What is the NMJ Nicotinic antagonist?
Pancuronium
Name the four muscarinic agonists
Acetylcholine
Pilocarpine
Methacholine
Bethanechol
Beta-1 agonist
Dobutamine
