Pharmacogenetics

Question 1

Goal of Pharmacogenetics:
To non-responders?
To toxic responders?

Answer 1

drug efficacy

drug safety

Question 2

Drug that causes G6PD deficiency in African-American leading to hemolytic anemia

Answer 2

Primaquine

Question 3

What is Alcaptonuria?

What enzyme is absent?

Answer 3

excretion of alkapton in the urine;

congenital absence of homogentisate 1,2-dioxygenase

Question 4

4 Mendelian Principles

Answer 4

1. Genes in pairs
2. Law of Dominance and Recessiveness
3. Law of Segregation
4. Law of Independent Assortment

Question 5

Stop Codons

Start Codon

Answer 5

UAG, UGA, UAA

AUG

Question 6

Methods used in Molecular Genotyping

Answer 6

PCR and Restriction Fragment Length Polymorphism Mapping

Question 7

The drug used to probe the activity of CYP450

Answer 7

Drebisoquine - antihypertensive