Autacoids Tangina

Question 1

Characteristics of Autacoids

Answer 1

1. endogenous
2. restricted to area of synthesis
3. short duration, involves response to injury

Question 2

5 main types of Autacoids

Answer 2

P-BASH

1. Prostanoids
2. Bradykinins
3. Angiotensin
4. Serotonin
5. Histamine

Question 3

Review of Inflammation:
It is the ___ line of defense against pathogen invasion.
Describe pathway.

Answer 3

2nd line.
Damage tissue release Histamine —> inc in blood flow to area —> capillary leakage —> release of phagocytes and clotting factors —> phagocytes engulf bacteria, platelets seal wounds

Question 4

Histamines:

Precursor? Enzyme? Storage cell? Where is it released?

Answer 4

• Histidine;
• L-histidine decarboxylase;
• stored in MAST CELLS and BASOPHILS;
• Released during physicochemical insults including neoplasms and allergies.

Question 5

Histamines:

Name 3 histamine agonists.

Answer 5

2-methylhistamine
4-methylhistamine
alpha-methylhistamine