Pharmacogenetics Flashcards
1
Q
Codeine
A
Starts as a prodrug and is metabolized in the liver
2
Q
Which races have difficulty converting codeine into active morphine?
A
Asian, Caucasian or middle eastern
3
Q
What is the significance of codeine with women?
A
They are ultrametabolizers of it so they get a lot less benefit from smaller doses
4
Q
Warfarin
A
Inhibits vitamin K epoxide to prevent thrombosis, CYP2C9 and VKORC1
5
Q
Why is warfarin so difficult to give?
A
You have to check it regularly to make sure it is enough to prevent thrombosis but avoid excessive bleeding
6
Q
What is the main use for ERT?
A
To help treat Lysosomal storage diseases
